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Diss Factsheets
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EC number: 431-460-4 | CAS number: 10061-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 87/302/EWG, B.29; OECD 413 (1981)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Details on test material:
- Batch no : A4305 05008
Test animals
- Species:
- other: rat, Wistar Crl:(WI)WU BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: None.
- Details on inhalation exposure:
- Method of exposure:
nose-only - Duration of treatment / exposure:
- Test duration: 90 days
- Frequency of treatment:
- Duration of exposure per day: 6 hours
Dosing regime: 5 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 0 mg/l
Male: 10 animals at 8.9 mg/l
Male: 10 animals at 26.9 mg/l
Male: 10 animals at 80.7 mg/l
Female: 10 animals at 0 mg/l
Female: 10 animals at 8.9 mg/l
Female: 10 animals at 26.9 mg/l
Female: 10 animals at 80.7 mg/l - Control animals:
- yes
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
There were no test substance related deaths.
No changes in breathing pattern or behaviour were observed.
No abnormalities were noted after exposure. Individual daily
observations prior to exposure revealed sparsely haired skin
in females exposed to 26.9 or 80.7 ppm. A significant
decrease in body weight gain was observed in males and
females exposed to 26.9 or 80.7 ppm. A significant decrease
in food intake was seen in males and females exposed to
80.7 ppm. Food conversion efficiency was also decreased in
males of this test group.
Laboratory findings:
Haematology revealed statistically significantly prolonged
prothrombin time in males exposed at 80.7 ppm.
Clinical biochemistry revealed statistically significantly
increases in alanine aminotransferase activity (males and
females), triglyceride concentration (females), and
albumin/globulin ratio (males) at 80.7 ppm when compared to
controls. The chloride concentration was decreased in a
concentration-related way and reached significance in males
exposed to 26.9 or 80.7 ppm and in females exposed to
80.7 ppm.
A statistically significantly increase in urinary volume and
a tendency towards decreased urinary density were found in
females exposed to 80.7 ppm.
Effects in organs:
After four weeks of exposure to 80.7 ppm statistically
significantly increased relative and absolute liver weights
were observed in females. Later after 13 weeks of exposure
relative weight of the liver was significantly increased in
both males and females. Absolute liver weight was also
significantly higher in females of this test group when
compared to controls. Relative weight of the kidneys was
statistically significantly increased in females exposed to
80.7 ppm.
No test substance-related macroscopic or microscopic
findings were recorded.
Effect levels
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- < 8.9 ppm
- Basis for effect level:
- body weight and weight gain
- organ weights and organ / body weight ratios
- urinalysis
- Dose descriptor:
- NOAEC
- Effect level:
- 0.04 mg/L air
- Based on:
- not specified
- Basis for effect level:
- body weight and weight gain
- organ weights and organ / body weight ratios
- urinalysis
Applicant's summary and conclusion
- Conclusions:
- Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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