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EC number: 234-499-3 | CAS number: 12007-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxic effects of chromium boride and carbide in rats.
- Author:
- Roshhina T.A.
- Year:
- 1 967
- Bibliographic source:
- Novye Dannye po Toksikologii Redkikh Metallov i Ikh Soedinenii, 166-71
Materials and methods
- Principles of method if other than guideline:
- Not specified. Only english abstract of russian article available.
Test material
- Reference substance name:
- Chromium diboride
- EC Number:
- 234-499-3
- EC Name:
- Chromium diboride
- Cas Number:
- 12007-16-8
- Molecular formula:
- B2Cr
- IUPAC Name:
- (boranylidynechromio)borane
Constituent 1
- Specific details on test material used for the study:
- Not specified. Only english abstract of russian article available.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified. Only english abstract of russian article available.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Remarks:
- Latushkina chamber
- Details on inhalation exposure:
- Inhalation contamination of rats by CrB2 dust was made in the Latushkina chamber (3 months every other day by 2 hrs.) at conentrations of 300-50 mg/m³
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 months, 2 hours/day
- Frequency of treatment:
- 3 months, 2 hours/day
Doses / concentrations
- Dose / conc.:
- 50 mg/m³ air
- Remarks:
- to 300 mg/m³
- No. of animals per sex per dose:
- not specified
Results and discussion
Results of examinations
- Details on results:
- The CrB2 and CrC had general toxic effect (decreases Hb content in blood), bronchitis, and cell prolifieration) with CrB2 acting more strongly. The intratracheal administering of CrC and CrB2 (50 mg) to rats caused changes in protein fractions of blood serum, and dust incapsulated foci, peribronchitis, perivascular and peribronchial sclerosis in lungs. The lung tissue reaction to the CrC and CrB2 was similar to that of chromite dust but was more strong. The CrC and CrB2 were less toxic than Cr anhydride and oxide.
Applicant's summary and conclusion
- Conclusions:
- The CrC and CrB2 were less toxic than Cr anhydride and oxide.
- Executive summary:
Inhalation contamination of rats by CrB2 and CrC were made in the Latushkina chamber (exposure over 3 months on each day with 50-300 mg/m³). The CrB2 and CrC had general toxic effect (decreases Hb content in blood), bronchitis, and cell proliferation) with CrB2 acting more strongly. The intratracheal administering of CrC and CrB2 (50 mg) to rats caused changes in protein fractions of blood serum, and dust incapsulated foci, peribronchitis, perivascular and peribronchial sclerosis in lungs. The lung tissue reaction to the CrC and CrB2 was similar to that of chromite dust but was stronger. The CrC and CrB2 were less toxic than Cr anhydride and oxide.
Based on the lacking information on study design and study results the publication was assigned with a Klimisch score of 4 and will not be used for regulatory purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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