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Diss Factsheets
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EC number: 273-960-3 | CAS number: 69300-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The method used to assess eye irritancy is a modification of that prescribed for the purposes of the United States Federal Hazardous Substances Labelling Act (Federal Register, 1964, 29, 13009).
In addition corneal damage is assessed objectively by measurement of corneal swelling (Burton, 1972, Food Cosm. Toxicol. 10, 209) - GLP compliance:
- no
- Remarks:
- study pre-dates introduction of GLP
Test material
- Reference substance name:
- 2-methyldecanenitrile
- EC Number:
- 273-960-3
- EC Name:
- 2-methyldecanenitrile
- Cas Number:
- 69300-15-8
- Molecular formula:
- C11H21N
- IUPAC Name:
- 2-methyldecanenitrile
- Reference substance name:
- Unknown impurities
- Molecular formula:
- Unknown
- IUPAC Name:
- Unknown impurities
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Substance tested: 2-methyldecanonitrile
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- New Zealand White rabbits weighing at least one kilogram and at least seven weeks old, bought from a commercial supplier are used in the rabbit eye irritation test. Usually 6 animals are used to test each experimental material.
The animals are kept before and after the test singly in cages, from which all hay, straw or similar potentially irritant material is excluded. They are given water and a commercially available pelleted diet ad libitum. All animals are in good health at start of testing.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 10 μl: 50% and 100% (in Tween 80)
- Observation period (in vivo):
- 15 minutes and days 1,2 ,3 and 4 after treatment
Each day after application of the test material the corneal thickness is measured until there is no more swelling. - Number of animals or in vitro replicates:
- 4 animals used
Results and discussion
In vivo
Results
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- 10 μL of undiluted 2-methyldecanonitrile caused a slight corneal lesion (healing by day 3) in one rabbit and had no corneal effect on the other treated. Both had very slight conjunctivitis present at only 15 minutes.
10 μL of 50% 2-methyldecanonitrile caused moderate corneal opacities in the two animals treated (the lesions were still present as grade 0.5 , on day 4 when the test ended). There was slight conjunctivitis in both rabbits. Discharge was slight in both rabbits., one rabbit had slight iritis.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 10 μL of undiluted 2-methyldecanonitrile caused a slight corneal lesion (healing by day 3) in one rabbit and had no corneal effect on the other treated. Both had very slight conjunctivitis present at only 15 minutes.
10 μL of 50% 2-methyldecanonitrile caused moderate corneal opacities in the two animals treated (the lesions were still present as grade 0.5 , on day 4 when the test ended). There was slight conjunctivitis in both rabbits. Discharge was slight in both rabbits.
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