Registration Dossier
Registration Dossier
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EC number: 203-918-1 | CAS number: 111-88-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of octane-1-thiol to micro-organisms has been read across from tert-dodecanethiol. Gancet (2010) showed the respiration of activated sludge was not affected by tert-dodecanethiol up to a concentration of 8.6 mg/l. Jenkins (1990) showed the EC50 for tert-dodecanethiol could not be calculated as it was not inhibitory to activated sludge at the concentrations tested, however it must be > 10 g/l.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 8.6 mg/L
Additional information
The toxicity of octane-1 -thiol to micro-organisms has been read across from tert-dodecanethiol. Gancet (2010) is a GLP-compliant activated sludge respiration inhibition test following OECD guidelines 309. The study has been assigned a Klimisch score of 1 - reliable without restriction (Klimisch et al, 1997) and is considered reliable and suitable for use for this endpoint.
This is supported by Jenkins (1990) is a 3 -hour, static, freshwater, GLP-compliant study on tert-dodecanethiol, testing oxygen consumption, following OECD guideline 309. The validity criteria were fulfilled. The study is considered reliable and adequate for assessment. The toxicity level given is not precise, but provides a minimum toxicity level.
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