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EC number: 203-623-8 | CAS number: 108-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Please refer to analogue justification provided in IUCLID section 13
Data source
Reference
- Reference Type:
- publication
- Title:
- The Inhalation Hazard Test; principle and method
- Author:
- Klimisch, H.-J.
- Year:
- 1 988
- Bibliographic source:
- Arch Toxicol 61:411 - 416
Materials and methods
- Principles of method if other than guideline:
- The acute toxic potential following inhalation was determined according to the Inhalation Hazard Test. Animals were exposed to a fixed concentration (66 mg/L) and the time after which no or 50% of test animals dies was determined.
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- no
Test material
- Reference substance name:
- Chlorobenzene
- EC Number:
- 203-628-5
- EC Name:
- Chlorobenzene
- Cas Number:
- 108-90-7
- Molecular formula:
- C6H5Cl
- IUPAC Name:
- chlorobenzene
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: not specified
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: whole-body exposure system (only general information given)
- Exposure chamber volume: 1 - 2L
- System of generating particulates/aerosols: Glass flask generator. The part of the generator containing the glass fritt and filled with the test substance dips into a thermostated liquid bath kept at the 20 °C
- Temperature in air chamber: saturation temperature (e.g. 20 °C)
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically from the weight loss of the material and the volume of air passing through the generator
- Concentrations:
- 66 mg/L (saturated vapour pressure at 20 °C)
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: LT50
- Effect level:
- 66 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1.8 h
- Remarks on result:
- other: Exposure for 1.8 h to 66 mg/L test substance resulted in mortality of 50% of test animals within the 14 day observation period.
- Sex:
- male/female
- Dose descriptor:
- other: LT0
- Effect level:
- 66 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 0.17 h
- Remarks on result:
- other: Exposure for 0.17 h to 66 mg/L test substance did not result in any mortality within the 14 day observation period.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 29.7 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Calculation according to Haber`s law (C∙t = k)
- Mortality:
- 66 mg/L: 3/6 animals died after exposure for 1.8 h
- Clinical signs:
- other: not examined
- Body weight:
- not examined
- Gross pathology:
- not examined
Any other information on results incl. tables
The Inhalation Hazard Test was performed to determine the hazard of volatile substances including chlorobenzene. 3 male and 3 female animals were exposed to 66 mg/L (nominal concentration) in a glass system with tubes.
For the generation of a vapor saturated inhalation atmosphere, a glass flask generator was used. The LT0 (time T after which no animals died within 14 days of post-exposure observation period) and the LT50 (time of exposure after which 50% of the animals died within 14 days of the post-exposure observation period) were calculated.
In this inhalation hazard test, the value of LT0 was 0.17 h and the value of LT 50 was 1.8 h.
The LC50 was calculated according to the Haber´s law: LC50= 66 mg/L (1.8 h /4 h) = 29.7 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- CLP: Acute Tox. 4, H332
Although available data on acute toxicity following inhalation do not meet the classification criteria according to Regulation (EC) 1272/2008, the registrant follows the harmonised classification.
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