Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-559-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Nov 2013 – 07 Mar 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesanstalt für Umwelt, Messungen und Naturschutz Baden-Würtemberg, Germany
- Analytical monitoring:
- yes
- Details on sampling:
- Analytical samples were taken from all test concentrations and control(s) at test start, after 24 and 48 hours. The control and all test item concentrations were analysed at 0 hours from fresh test solutions and at 24 hours from aged and fresh test solutions.
- Vehicle:
- no
- Details on test solutions:
- The necessary amount of Ammonium Niobium Oxalate for preparing the stock solution was weighed on weighing scoops and transferred to a volumetric flask. Test medium was added up to the bench mark and the solution was homogenised by shaking. The lower test solutions were prepared by dilution of the stock solution. Defined volumes of the prepared solution were transferred to each test vessels.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Clone V
- Source: Continuously bred in the laboratory. Originally purchased in a healthy condition from the Umweltbundesamt (Federal Environment Agency) in Berlin/Germany
- Age at study initiation (mean and range, SD): max. 24 hours old
- Method of breeding: Daphnia magna was reared as single culture where one daphnid is kept per 100 mL. The pH-value of the aerated water was within a range of 6.0 – 9.0. The dissolved oxygen was above 60 % saturation and the total hardness 140 - 250 mg/L (as CaCO3), corresponding to 7.8 - 14°dH. Daphnids reared at a temperature of 20 ± 2 °C in a climatic chamber with 16 hours of illumination and 8 hours of darkness.
- Feeding during test: none
- Food type: green alga Desmodesmus subspicatus
- Frequency: three times a week - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 179 mg/L CaCO3; 10 °dH
- Test temperature:
- 18.8 – 20.1 °C
- pH:
- 7.14 – 8.39
- Dissolved oxygen:
- ≥ 8.6 mg/L
- Nominal and measured concentrations:
- control, 0.842, 2.19, 5.69, 14.8, 38.5 and 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL glass beakers, filled with 50 mL test solution
- Aeration: none
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 10 mL of test solution for each animal
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The test medium was water composed of dechlorinated drinking water and deionised water.
- Intervals of water quality measurement: Temperature, pH-value and oxygen concentration of the test solutions measured after 0, 24 and 48 hours. Hardness of the test water was measured on the day of application.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light, 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): After 24 h and 48 h the immobilised daphnids were counted. If present, behavioural changes of daphnids were recorded at 24 and 48 hours after starting the test.
TEST CONCENTRATIONS
- Spacing factor for test concentrations in main test: 2.6
- Range finding study:
Test concentrations: 0, 0.01, 0.1, 1.00, 10.0 and 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 34 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 34 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: After 24 and 48 hours a fine, white precipitate was observed at the test item concentration of 14.8 mg/L. More precipitate was observed at the test item concentration of 38.5 mg/L and at the highest test item concentration of 100 mg/L the bottom of the test vessel was completely covered with precipitate
- Results with reference substance (positive control):
- The results indicate an EC50 (24 h) of the reference item potassium dichromate between 1.0 and 2.0 mg/L. Since the results fall within the historical data generated with the reference item at the testing facility and are within the range of 0.6 – 2.1 mg/L recommended by the test guideline OECD 202, the daphnids were suitable for the determination of the toxicological effects of the test item.
- Reported statistics and error estimates:
- Since no immobilisation above the allowed control immobilisation of 10 % was observed at the highest test item concentration of 100 mg test item/L, no statistical determination was indicated.
Reference
Analytical monitoring:
The initial measured concentrations in the test item solutions ranged from 84% to 113% of nominal with a mean initial concentration at 101% of nominal. The measured concentrations in the aged test item solutions ranged from 11% to 45% of nominal with a mean concentration at 25% of nominal. Toxicological endpoints were therefore evaluated using nominal concentrations and actual concentrations based on the geometric means of the analysed concentration levels.
Table: Determined concentration of Ammonium Niobium Oxalate during analytical monitoring
Test item nominal [mg/L] |
Nb nominal [mg/L] |
Sampling |
Nb |
Test item actual [mg/L] |
||
[mg/L] |
% of nominal |
Geometric mean* |
||||
0 |
0 |
0h fresh |
n.d. |
- |
- |
- |
24h fresh |
n.d. |
- |
||||
24h aged |
n.d. |
- |
||||
0.842 |
0.145 |
0h fresh |
0.147 |
102 |
67 |
0.564 |
24h fresh |
0.139 |
96 |
||||
24h aged |
0.066 |
45 |
||||
2.19 |
0.377 |
0h fresh |
0.349 |
93 |
60 |
1.31 |
24h fresh |
0.399 |
106 |
||||
24h aged |
0.136 |
36 |
||||
5.69 |
0.979 |
0h fresh |
0.922 |
94 |
50 |
2.85 |
24h fresh |
0.987 |
101 |
||||
24h aged |
0.258 |
26 |
||||
14.8 |
2.55 |
0h fresh |
2.70 |
106 |
46 |
6.81 |
24h fresh |
2.66 |
104 |
||||
24h aged |
0.52 |
20 |
||||
38.5 |
6.62 |
0h fresh |
5.59 |
84 |
33 |
12.7 |
24h fresh |
7.22 |
109 |
||||
24h aged |
0.71 |
11 |
||||
100 |
17.2 |
0h fresh |
17.3 |
101 |
34 |
34.0 |
24h fresh |
19.5 |
113 |
||||
24h aged |
1.94 |
11 |
||||
Mean value fresh test solutions |
101 |
|
|
|||
Mean value aged test solutions |
25 |
|
|
- = not calculated; n.d. = not detectable; LOQ = 0.251 mg/L Ammonium Niobium Oxalate corresponding to 0.0432 mg/L Nb
*mean values of fresh test solutions and single values of aged test solutions per concentration level were used for calculation of geometric means
Table: Immobilisation of Daphnia after 48 hours
Concentration Test Item |
Control |
0.842 |
2.19 |
5.69 |
14.8 |
38.5 |
100 |
|
|
[mg/L] |
|||||
|
immobilised daphnids after 48 h |
||||||
Group 1 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
Group 2 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
Group 3 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
Group 4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Σ |
0 |
0 |
1 |
1 |
0 |
0 |
1 |
% |
0 |
0 |
5 |
5 |
0 |
0 |
5 |
Description of key information
EC50 (48h) > 100 mg/L with Daphnia magna (nominal, OECD 202)
EC50 (48h) > 34 mg/L with Daphnia magna (measured, geometric mean, OECD 202)
Key value for chemical safety assessment
Additional information
One study investigating the acute toxicity of Reaction mass of ammonium diaqua[bis(oxalate)]oxoniobate(1-) hydrate and ammonium hydrogen oxalate oxalic acid (1:1:1) dihydrate to Daphnia magna is available. The study was conducted with six concentrations of the test item in the range from 0.842 to 100 mg/L. The test was performed in a semi-static design according to OECD 202 (CBMM Europe BV, Key, 2014, Daphnia magna). After 24 hours one immobilised Daphnia each was found at 2.19, 5.69, and 100 mg/L. Thus, no significant mortality occurred at any test concentrations within 48 hours. There were, however, difficulties in the performance of the test, due to the chemical behaviour of the test item, which tends to form complexes in solution. After 24 and 48 hours a fine, white precipitate was observed at the test item concentration of 14.8 mg/L. More precipitate was observed at the test item concentration of 38.5 mg/L and at the highest test item concentration of 100 mg/L the bottom of the test vessel was completely covered with precipitate. Recovery rates were low: while analytical monitoring showed the initial mean measured concentration to be 101% of nominal, the mean measured concentration in the aged test item solutions was only 25% of nominal. The endpoints were therefore evaluated using nominal concentrations and actual concentrations based on the geometric means of the analysed concentration levels. Thus, the EC50 being > 100 mg/L (based on nominal concentration) and > 34 mg/L (based on geometric mean measured concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.