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EC number: 205-132-4 | CAS number: 134-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from modelling database
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- ECOSAR v1.1
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- -Common name: Water Flea
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 21 d
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 4.36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: other details not available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of EPI suite, ECOSAR version 1.11, the EC 50 value for long term toxicity to aquatic invertebrates was predicted to be 4.36mg/l for test chemical in 21 days.
Based on this value it can be concluded that the substance was considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation. - Executive summary:
Based on the prediction done by EPI suite, ECOSAR version 1.11, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted.
On the basis of this program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted to be 4.36 mg/l for test chemical in 21 days. Based on this value it can be concluded that the substance was considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.
Reference
Description of key information
Based on the prediction done by EPI suite, ECOSAR version 1.11, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted.
On the basis of this program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted to be 4.36 mg/l for test chemical in 21 days. Based on this value it can be concluded that the substance was considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.36 mg/L
Additional information
Predicted study for target chemical and experimental study for its structurally similar read across chemical have been reviewed to determine the long term toxicity of test chemical to aquatic invertebrates and their results are summarized below.
The first study based on the prediction done by EPI suite, ECOSAR version 1.11, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted. On the basis of this program, the EC 50 value for long term toxicity to aquatic invertebrates was predicted to be 4.36 mg/l for test chemical in 21 days. Based on this value it can be concluded that the substance was considered to be nontoxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.
Next study reviewed from journal water Research in this An experiment was conducted to determine the long term toxicity of test chemical aquatic invertebrates using DIN-Standard 38412, Part II guideline for 21 days reproduction test. The test organism used in this study was Daphnia magna ((IRCHA strain). The stock solution of test chemical of concentration 400 mg/L was prepared by stirring test chemical in water for 1 h. The nominal concentration of test chemical used were in range of 0.4-100 mg/L. The experiment was conducted in semi-static condition using fresh water (Berlin tap water) in 2 litre capacity beaker and it was covered by watch glass, the number of organism per vessel were 20-30.The test chemical solutions of different nominal concentrations were exposed Daphnia manga for 21 days in replicates at temperature 20°C and pH 7.6-7.7 the test solution was oxygen saturated. The analytical monitoring of test chemical solution was done by using chemical method. After 21 days of exposure of test chemical to Daphnia magna the EC50 value and NOEC value was determined to be 7 mg/L and 13 mg/L.
Last study was reviewed from authoritative database in this an experiment was conducted to determine the long term toxicity of test chemical aquatic invertebrates OECD Guideline 211 (Daphnia magna Reproduction Test). The test organism used in this study was Daphnia magna. The experiment was conducted in semi-static condition using fresh water. The test chemical solutions of different nominal concentrations were exposed Daphnia manga for 21 days. After 21 days of exposure of test chemical to Daphnia magna the EC50 value and NOEC value was determined to be 1.2 mg/L and 0.71 mg/L.
By considering results of all the study mentioned above the EC50 value of test chemical was determined to be in range of 1.2 to 13 mg/L after exposure of test chemical for 21 days to daphnia magna. By considering range EC50 value it is concluded that test chemical non-toxic to aquatic organisms and cannot be classified as per CLP regulation
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