Registration Dossier
Registration Dossier
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EC number: 246-426-2 | CAS number: 24717-85-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 September to 15 November 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Federal Office for the Environment (FOEN)
- Type of method:
- slow-stirring method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.99
- Temp.:
- 25 °C
- Remarks on result:
- other: pH is not reported
- Conclusions:
- A log Pow of 5.99 ± 0.10 at 25°C was determined for the test substance according to OECD 123.
Reference
Results
Thermostated glass flasks containing the aqueous phase and n-octanol were slowly stirred, after dosing the test item dissolved in octanol, until equilibrium distribution of the test item between the two phases was achieved. The temperature was kept constant at 25 °C ± 1 °C. The concentration of the test item in the phases was measured by HPLC/UV. The partition coefficient (n-octanol/water) log Pow was calculated. The equilibrium distribution was defined to be achieved, when four sampling intervals separated by at least 5 hours yielded similar log Pow values, expressed by a plateau with zero slope. The testing was performed in triplicate.
The results of the individual measurements of the slow-stirring test and the calculation of the log Pow values are given in the table below.
Slow-Stirring Test - Results obtained for log Pow.The tabulated values of the samples represent rounded results obtained by calculation using the exact data.
Stirring Time [hours] |
Measured Concentration in n- Octanol [μg/L] |
Measured Concentration in Water [μg/L] |
Log Pow |
|||||||
|
Test 1 |
Test 2 |
Test 3 |
Test 1 |
Test 2 |
Test 3 |
Test 1 |
Test 2 |
Test 3 |
mean |
168 |
20961179 |
20525802 |
21014367 |
11.1 |
16.3 |
17.8 |
6.28 |
6.1 |
6.07 |
6.15 |
173 |
22206444 |
22625919 |
20681529 |
18.8 |
25.2 |
32.8 |
6.07 |
5.95 |
5.8 |
5.94 |
192 |
19810775 |
20643146 |
22907214 |
18.4 |
24.2 |
31.5 |
6.03 |
5.93 |
5.86 |
5.94 |
197 |
17405237 |
21014916 |
21071394 |
18.3 |
24.7 |
32 |
5.98 |
5.93 |
5.82 |
5.91 |
Means: |
6.09 |
5.98 |
5.89 |
5.99 |
||||||
Overall mean |
5.99 ± 0.10 (1.7% RSD) |
|||||||||
Description of key information
Log Pow: 5.99 ± 0.10 at 25°C (OECD 123, Slow-Stirring Method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.99
- at the temperature of:
- 25 °C
Additional information
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