Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
1. SOFTWARE
ECOSAR Profile

2. MODEL (incl. version number)
ECOSAR Version 1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CCN1CCN(C(=O)NC(C(=O)(O))c2ccccc2)C(=O)C1(=O)

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish

5. APPLICABILITY DOMAIN
- Structural and mechanistic domains: Carbonyl Ureas -acid

Data source

Reference
Reference Type:
other: QSAR model
Title:
EPI Suite v 4.1/ECOSARv1.11
Author:
US EPA
Year:
2011
Bibliographic source:
http://epa.gov/oppt/exposure/pubs/episuite.htm

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH Guidance on QSARs R.6
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Effect concentrations
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 948.63 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
mortality
Remarks on result:
not measured/tested

Applicant's summary and conclusion

Conclusions:
LC50 (96h) 1948.63 mg/l is predicted.