Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-076-3 | CAS number: 299-29-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- Iron digluconate
- EC Number:
- 206-076-3
- EC Name:
- Iron digluconate
- Cas Number:
- 299-29-6
- Molecular formula:
- C12H22FeO14
- IUPAC Name:
- λ²-iron(2+) bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
- Details on test material:
- Ferrous gluconate
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 10 days
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
Any other information on results incl. tables
Ferrous Gluconate was not mutagenic at any exposure level used. Ferrous Gluconate was devoid of mutagenic properties.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
ferrous gluconate is devoid of mutagenic properties. - Executive summary:
This substantial paper is principally an introduction to the method. The Drosophila test is considered to check for mutations at 600 to 800 loci. It can detect both point mutagens and promutagens which require activation. Ferrous gluconate was one of 421 substances tested. The objective being to correlate known carcinogenic properties with this mutagenic end-point. The authors of the study, reviewed in this US-EPA report, found ferrous gluconate to be devoid of mutagenic properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
