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Diss Factsheets
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EC number: 478-250-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 478-250-9
- EC Name:
- -
- Cas Number:
- 62965-37-1
- Molecular formula:
- C26H42N2O4
- IUPAC Name:
- (2S)-2-{[(benzyloxy)carbonyl]amino}-3,3-dimethylbutanoic acid; N-cyclohexylcyclohexanamine
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- A sample of activated sludge was collected from the aeration tank at Worlingworth sewage treatment works, which treats predominantly domestic
waste. Aliquots (25 ml) of a homogenised sample were filtered through dried (approximately 105°C) and pre-weighed Whatman GF/C filter papers.
The filters were dried for at least one hour, allowed to cool and re-weighed. The solids level in the sludge was determined and then an appropriate
volume used to inoculate control and test vessels to give a final suspended solids concentration of 30 mg/l - Duration of test (contact time):
- 29 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- Mean cumulative CO2 production by the mixtures containing VRT-126017 dcha was equivalent to 10% of the TCO2 after approximately 7 days and 54% by the end of the test on Day 29.
The pH of each test and control mixture was 7.6 at the start of the test and ranged from 7.4 to 7.6 at the end.
The rate of air flow during the test ranged from 40 to 75 ml/minute.
The temperature of a three-litre volume of water held under the test conditions ranged from 21.7°C to 22.7°C during the test period
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 2 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 13
- Sampling time:
- 8 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 47
- Sampling time:
- 17 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 53
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 54
- Sampling time:
- 29 d
BOD5 / COD results
- Results with reference substance:
- 23 % degradation after 2 d
45 % degradation after 4 d
61 % degradation after 6 d
68 % degradation after 8 d
71 % degradation after 9 d
73 % degradation after 10 d
75 % degradation after 13 d
78 % degradation after 17 d
81 % degradation after 22 d
84 % degradation after 28 d
85 % degradation after 29 d
Applicant's summary and conclusion
- Conclusions:
- The mean cumulative CO2 production by mixtures containing VRT-126017 dcha at 9.4 mgC/l was equivalent to 10% of the TCO2 after approximately 7 days and 54% by the end of the test on Day 29. The test item cannot considered to be readily biodegradable.
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