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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Epidemiological data

Currently viewing:

Administrative data

Endpoint:
epidemiological data
Type of information:
other: epidemiology
Adequacy of study:
supporting study
Rationale for reliability incl. deficiencies:
other: Only abstract available (study in Chinese)

Data source

Reference
Reference Type:
publication
Title:
Chronic toxic effect of chloroethanol
Author:
Yu X, Li Y, Wang Y, Lui J, Li M
Year:
1997
Bibliographic source:
Gongye Weisheng Yu Zhiyebing 23(1): 31-32

Materials and methods

Study type:
cohort study (retrospective)
Endpoint addressed:
repeated dose toxicity: inhalation
Principles of method if other than guideline:
Toxic effects in workers exposed during working shift to the test substance for more than 2 years
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloroethanol
EC Number:
203-459-7
EC Name:
2-chloroethanol
Cas Number:
107-07-3
Molecular formula:
C2H5ClO
IUPAC Name:
2-chloroethan-1-ol
Details on test material:
no details

Method

Details on study design:
Contact level and chronic toxic effects in 61 workers in a chloroethanol workshop studied; 60 workers without toxic substance contact history served as controls .
Exposure assessment:
measured

Results and discussion

Results:
In analytical workers the incidence of neurothenia and anorexia were significantly increased; blood cholesterol level was significantly higher (comment: comparison to normal range questionable).
Two cases of salivary antipyrine clearance below 30 ml/min., indicating possible mixed function oxidase inhibition; RUN, glutathione content, LDH isoenzyme, transpeptidase, urinary beta .2-microglobulin, blood and urine routine, liver function test, EGG and EEG were normal.
No further data
Confounding factors:
no data
Strengths and weaknesses:
not assignable

Any other information on results incl. tables

Small cohort size

Applicant's summary and conclusion

Conclusions:
In a chinese cohort study on workers exposed to an average of 4 mg/m³ per shift for more than 2 years a significant increase in the incidence of neurothenia and anorexia was found, however, the study was hampered by small cohort size.
Executive summary:

Chronic toxic effects in 61 chinese workers in a chloroethanol workshop were studied and compared with 60 workers without toxic substance contact history (only abstract available, no details). The average exposure level was 4 mg/m³ and the average exposure duration 11 years. The incidence of neurothenia and anorexia were significantly increased; blood cholesterol level was significantly higher.

Conclusion: In a chinese cohort study on workers exposed to an average of 4 mg/m³ per shift for more than 2 years a significant increase in the incidence of neurothenia and anorexia was found, however, the study was hampered by small cohort size.