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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ECOSAR Profile
2. MODEL (incl. version number)
ECOSAR Version 1.11
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
Oc1cccc2cccnc12
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish
5. APPLICABILITY DOMAIN
- Structural and mechanistic domains: Phenols - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
- Specific details on test material used for the study:
- Structural information
SMILES:
Oc1cccc2cccnc12
Numerical identifiers
EC#: 205-711-1
CAS#: 148-24-3
Chemical names:
8-Hydroxyquinoline
8-hydroxyquinoline (
oxyquinoline) (8-qui
nolinol)
8-Quinolinol - Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- other: Fish specie not specified
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 45 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- not specified
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- Values used to Generate ECOSAR Profile -------------------------------------- Log Kow: 1.662 (EPISuite Kowwin v1.68 Estimate) Wat Sol: 417 (mg/L, PhysProp DB exp value)
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (96h) 45 mg/l is predicted.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
QSAR Toolbox
2. MODEL (incl. version number)
QSAR Toolbox 4.1
Database version: 4.1
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
Oc1cccc2cccnc12 CAS: 148-24-3
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish
5. APPLICABILITY DOMAIN
- Structural and mechanistic domains:
Database(s) used:
- Aquatic ECETOC
- Aquatic OASIS
- ECHA CHEM
- ECOTOX
Category boundaries (applicability domain):
- Active descriptor(s) range:
- log Kow: from 1.51 to 6.39 target chemical is in domain
- Response range:
- EC50LC50: from 3.38 to 6.63 log(1/mol/L) (from 0.0612 to 44.7 mg/L)
Profilers:
- US-EPA New Chemical Categories (primary grouping) target chemical is in domain
- Substance type (subcategorization) target chemical is in domain
- US-EPA New Chemical Categories (subcategorization) target chemical is in domain
- Aquatic toxicity classification by ECOSAR (subcategorization) target chemical is in domain
- Organic functional groups, Norbert Haider (checkmol) (subcategorization) target chemical is in domain
Additional data pruning:
Data inconsistency filter 8 value(s) from 7 chemical(s)
Filter by water solubility 25 value(s) from 11 chemical(s)
Manually eliminated data points:
none - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance of QSARs R.6
- GLP compliance:
- no
- Specific details on test material used for the study:
- Structural information
SMILES:
Oc1cccc2cccnc12
Numerical identifiers
EC#: 205-711-1
CAS#: 148-24-3
Chemical names:
8-Hydroxyquinoline
8-hydroxyquinoline (
oxyquinoline) (8-qui
nolinol)
8-Quinolinol - Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Predicted endpoint (OECD Principle 1 - Defined endpoint): Ecotoxicological Information -> Aquatic Toxicity -> Pimephales promelas -> EC50
LC50 -> Mortality -> Animalia (animals) -> Chordata (chordates) -> Actinopterygii (ray-finned fishes,spiny rayed fishes) -> 96 h - Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 65.2 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Data gap filling method: Trend analysis, executed via AW "Ecotoxicological Endpoint"
- Validity criteria fulfilled:
- yes
- Conclusions:
- This report contains a QSAR prediction for the substance Quinoli-9-ol (CAS number: 148-24-3). The targeted susbtance was predicted to have an EC50 (mortality) of 65.2 mg/l. The large amount of experimental data on analogues assures a good reliability of the prediction and therefore it is considered to fulfil the minimun acceptance criteria.
- Executive summary:
Based on the prediction done using the OECD QSAR toolbox version 4.1 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on fish was predicted for Quinolin-8 -ol
(CAS no 148 -24 -3). EC50 value was estimated to be 65 mg/L on the basis of intoxication for Pimephales promelas for 96 hrs duration. Hence, Quinolin-8 -ol was considered being low hazardous to aquatic vertebrates at environmentally relevant concentrations. Testing on fish was considered unneccesary since alternatives to animal testing showed a good reliability.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
VEGA
2. MODEL (incl. version number)
Fathead Minnow LC50 96h (EPA) 1.0.7
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
Oc1cccc2cccnc12
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish
5. APPLICABILITY DOMAIN
Global AD Index
AD index = 1
Explanation: the predicted compound is into the Applicability Domain of the model.
Similar molecules with known experimental value
Similarity index = 0.867
Explanation: strongly similar compounds with known experimental value in the training set have been found.
Accuracy of prediction for similar molecules
Accuracy index = 0.059
Explanation: accuracy of prediction for similar molecules found in the training set is good.
Concordance for similar molecules
Concordance index = 0.449
Explanation: similar molecules found in the training set have experimental values that agree with the predicted
value.
Maximum error of prediction among similar molecules
Max error index = 0.078
Explanation: the maximum error in prediction of similar molecules found in the training set has a low value,
considering the experimental variability. - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
- Specific details on test material used for the study:
- Structural information
SMILES:
Oc1cccc2cccnc12
Numerical identifiers
EC#: 205-711-1
CAS#: 148-24-3
Chemical names:
8-Hydroxyquinoline
8-hydroxyquinoline (
oxyquinoline) (8-qui
nolinol)
8-Quinolinol - Analytical monitoring:
- not required
- Test organisms (species):
- other: Fathead Minnow
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 63.13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Predicted toxicity [mg/l]: 63.13
- Validity criteria fulfilled:
- no
- Conclusions:
- Prediction is 63.13 mg/L
Referenceopen allclose all
Description of key information
Testing on the aquatic vertebrates was considered not necessary as alternatives to testing were available and they demonstrated to be sufficient to fulfil the legal requirements related to Annex VIII, Section 9.1.3 of REACH. Therefore, the general rules for adaptation 1.2 and 1,3 of Annex XI of REACH regulation are met and applied. Furthermore, the substance is classified as Aquatic Acute 1 and Aquatic Chronic 1 (Harmonised classification according to Annex VI of CLP). The results obtained from the three QSAR models (QSAR Toolbox, VEGA and ECOSAR) were in the EC50 range: 45 -65,2 mg/l. The EC50 of 58.44 mg/l has been chosen as key for the CSA (average of the three QSAR predictions).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 58.44 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 58.44 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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