Registration Dossier
Registration Dossier
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EC number: 202-620-9 | CAS number: 97-94-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP with limited details of the study, however, considered sufficient for classification
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Studies on the Toxicity of Triethylhorane (TEB)
- Author:
- Rinehart, W.
- Year:
- 1 960
- Bibliographic source:
- American Industrial Hygiene Association Journal (1958-1999), (1960) Vol. 5, pp. 389-93
- Report date:
- 1960
- Reference Type:
- publication
- Title:
- Toxicology of Boron Compounds
- Author:
- Levinskas, G.
- Year:
- 1 964
- Bibliographic source:
- "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Triethylborane
- EC Number:
- 202-620-9
- EC Name:
- Triethylborane
- Cas Number:
- 97-94-9
- Molecular formula:
- C6H15B
- IUPAC Name:
- triethylborane
- Test material form:
- other: liquid
- Details on test material:
- 8.9% (w/w) solution of TEB in Nujol (77.9 mg TEB/ml solutin, density 0.872 gm/ml).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- None provided
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Nujol (mineral oil)
- Details on oral exposure:
- Test article was administered by stomach tube and observed for 7 days.
- Doses:
- The assay of the solution was based on boron contest as determined by the method of Hill (Rinehart, 1960).
10 animals were dosed with 50 mg TEB kg. Five animals each were dose with 159, 200, 252, 317 or 468 mg TEB/kg. - No. of animals per sex per dose:
- See above
- Details on study design:
- No additional information provided
- Statistics:
- The LD50 was calculated by the method of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 235 mg/kg bw
- Remarks on result:
- other: no further information
- Mortality:
- There were 0/10, 0/5, 0/5, 4/5, 5/5 and 5/5 for the 50, 159, 200, 252, 317 or 468 mg TEB/kg dose groups, respectively. Death occurred within 2-24 hours.
- Clinical signs:
- other: Anorexia and lassitude (all animals) and tremors and convulsions in animals that died.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 (rats) was 235 mg TEB/kg.
- Executive summary:
The acute oral LD50 (rats) was 235 mg TEB/kg.
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