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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from WHO report

Data source

Reference
Reference Type:
publication
Title:
SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
Author:
WHO FOOD ADDITIVES SERIES: 48
Year:
2002
Bibliographic source:
Fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) World Health Organization, Geneva, 2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute toxicity test was performed on male rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic
- Impurities (identity and concentrations): No data
Specific details on test material used for the study:
- Name of test material: 1,1-diethoxy-3,7-dimethylocta-2,6-diene
- Molecular formula: C14H26O2
- Molecular weight: 226.35 g/mole
- Smiles notation: O(C(OCC)C=C(CCC=C(C)C)C)CC
- Substance type: Liquid
- Physical state: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated male rat
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally.
Executive summary:

In a Acute toxicity test, male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene in the concentration of 5000 mg/kg bw orally. No mortality was observed in treated male rat at 5000 mg/kg bw. Therefore, LD50 was considered to be > 5000 mg/kg bw when male rat were treated with 1,1-diethoxy-3,7-dimethylocta-2,6-diene orally.