Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-276-9 | CAS number: 34893-92-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented and scientifically acceptable
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- a cotton swab soaked with 0.5 ml of compound was applied into the ear of 1-2 rabbits for 1, 8 or 24 h. Post-observation time was 7 days
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-dichloro-5-isocyanatobenzene
- EC Number:
- 252-276-9
- EC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Cas Number:
- 34893-92-0
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1, 8, or 24 h
- Observation period:
- up to 7 days
- Number of animals:
- 1-2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 1 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 1 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 8 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 8 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Remarks on result:
- other: exposure for 24 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 48 h
- Score:
- 1
- Max. score:
- 4
- Remarks on result:
- other: exposure for 24 h
- Other effects:
- no data
Any other information on results incl. tables
After the removal of the bandage there was no skin reaktion on 1 of the 2 animals treated for 1 hours and on both rabbits treated for 8 hours. The rabbit treated for 24 hours showed a strong erythema and up to 2 days a mildly edema.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
method: a cotton swab soaked with 0.5 ml of compound was applied into the ear of 1-2 rabbits for 1, 8 or 24 h. Post-observation time was 7 days
result: not irritating (application time: 1 or 8 h)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
