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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from IUCLID dataset

Data source

Reference
Reference Type:
review article or handbook
Title:
IUCLID Dataset - 2,2'-Methyliminodiethanol
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset- EUROPEAN COMMISSION – European Chemicals Bureau- 18–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study was conducted in rabbits for test chemical N-Methyldiethanolamine.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report):N-Methyldiethanolamine
- Molecular formula :C5H13NO2
- Molecular weight:119.163 g/mol
- InChI:1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data
Reversibility:
no data
Remarks on result:
other: Skin irritation was not observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test material N-Methyldiethanolamine (CAS No: 105-59-9) was observed to be not irritating on rabbits skin.
Executive summary:

The skin irritation test was carried out in rabbits to determine the skin irritation potency of test chemical N-Methyldiethanolamine (CAS No: 105-59-9) by Draize Test.

 No known skin reactions were observed. Therefore the test chemical N-Methyldiethanolamine (CAS No: 105-59-9) can be considered as not irritating to rabbits skin.