Registration Dossier
Registration Dossier
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EC number: 222-365-7 | CAS number: 3446-89-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- Principles of method if other than guideline:
- Five male rats were selected from available stock. On the day of dosing the appropriate dose volume was administered by gavage at a dose volume of 10 ml/kg, giving a dose level of 1000 mg/kg bw.
Animals were observed for signs of toxicity and other abnormalities at time of dosing, app. 1, 2 and 4 hr after dosing and daily thereafter for the fourteen day duration of the study.
Animal were subjected to a gross examination for abnormalities both eternal and of the thoracic cavity and abdominal viscera. Larger organs were sectioned and the gastro-intestinal tract was opened at intervals for examination of the mucosal surfaces. - GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(methylthio)benzaldehyde
- EC Number:
- 222-365-7
- EC Name:
- 4-(methylthio)benzaldehyde
- Cas Number:
- 3446-89-7
- Molecular formula:
- C8H8OS
- IUPAC Name:
- 4-(methylthio)benzaldehyde
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 1 000 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- No significan clinical signs were apparent following dosing.
- Body weight:
- Changes were within the normally expected for this strain and age of animal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No mortality occurred and no significan clinical signs were apparent following dosing. No abnormal findings were apparent at necropsy.
The test substance was essentially non-toxic when administered orally as a single dose at a level of 1000 mg/kg.
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