Registration Dossier
Registration Dossier
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EC number: 202-690-0 | CAS number: 98-66-8
Endpoint summary
Administrative data
Description of key information
The skin sensitization of the targetcompoundwas predicted employing two differentin silicoapproaches: the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree and Derek Nexus. The three predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction. In the weight of evidence assessment only reliable predictions are to be taken into account. In the case of the target4-Chlorobenzenesulfonic acid, Vega,Toxtree and Derek Nexus did not identify any skin sensitization reactivity domain alert, leading to a NEGATIVE prediction for skin sensitization. A detailed assessment of the reliability of the weight of evidence prediction was not possible.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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