Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-413-1 | CAS number: 140-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Principles of method if other than guideline:
- Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance p-tolyl acetate. The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test).
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- CAS number: 140-39-6
EC number: 205-413-1
- Name of test material (as cited in study report): 4-methylphenyl acetate
- Molecular formula (if other than submission substance): C9H10O2
- Molecular weight (if other than submission substance): 150.176 g/mol
- Smiles notation (if other than submission substance): c1(ccc(C)cc1)OC(C)=O
- InChI: 1S/C9H10O2/c1-7-3-5-9(6-4-7)11-8(2)10/h3-6H,1-2H3
- Substance type: Organic
- Physical state: Liquid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- other: BOD and ThOD
- Key result
- Parameter:
- other: % degradation as per BOD and ThOD
- Value:
- 84
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known
- Details on results:
- Test substance undergoes 84% degradation by BOD and ThOD parameter in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The percentage degradation of test substance was determined to 84% degradation by BOD and ThOD parameter in 28 days. Thus, based on percentage degradation, p-tolyl acetate is considered to be readily biodegradable in water.
- Executive summary:
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance p-tolyl acetate. The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) under aerobic conditions.The percentage degradation of test substance was determined to 84% degradation by BOD and ThOD parameter in 28 days. Thus, based on percentage degradation, p-tolyl acetate is considered to be readily biodegradable in nature.
Reference
Description of key information
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance p-tolyl acetate (CAS no. 140-39-6) (GSBL database, 2016). The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) under aerobic conditions. The percentage degradation of test substance was determined to 84% degradation by BOD and ThOD parameter in 28 days. Thus, based on percentage degradation, p-tolyl acetate is considered to be readily biodegradable in nature.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
In different studies, p-tolyl acetate has been investigated for potential for biodegradation to a greater or lesser extent. These incude 1 experimental study from authoritative database along with 2 predicted data for the target compound p-tolyl acetate (CAS no. 140 -39 -6) and the 3 studies (from authoritative database) for its closest read across substance with logKow as the primary descriptor.
In a study from authoritative database(GSBL database, 2016) for target chemical p-tolyl acetate (CAS No. 140 -39 -6), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance p-tolyl acetate. The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) under aerobic conditions. The percentage degradation of test substance was determined to 84% degradation by BOD and ThOD parameter in 28 days. Thus, based on percentage degradation, p-tolyl acetate is considered to be readily biodegradable in nature.
In another prediction for target chemical p-tolyl acetate(CAS No. 140-39-6) done using QSAR toolbox version 3.4 (2017), the test substance undergoes 69.5% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical p-tolyl acetate was estimated to be readily biodegradable in water.
Additional supporting data of biodegradation for target chemical p-tolyl acetate(CAS No. 140-39-6) is predicted using Estimation Programs Interface Suite (EPI suite, 2017) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1 -7, respectively) of the BIOWIN v4.10 software. The results indicate that p-tolyl acetate is expected to be readily biodegradable.
In a study reported for read across substance o-acetylsalicylic acid (CAS no. 50-78-2)which is having a percentage similarity of 50-60% with the target chemical p-tolyl acetate(J-CHECK, 2016), experiment was conducted for 28 days for evaluating the percentage biodegradability. Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l, respectively. At the beginning of the test, the pH of the test solution was adjusted. The percentage degradation of read across substance was determined to be 86, 97 and 100% degradation by BOD, TOC removal and HPLC parameter in 28 days. The read across substance was hydrolyzed to form Salicylic acid and Acetic acid in (Water + Test Substance) systems. Thus, based on percentage degradation, o-acetylsalicylic acid is considered to be readily biodegradable in nature.
In an additional study of read across substance Methyl acetoacetate (CAS no. 105-45-3) from authoritative database (J-CHECK, 2016), experiment was carried out for 14 days for evaluating the percentage biodegradability of the substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 78, 98 and 100% degradation by BOD, TOC removal and HPLC parameter in 14 days. Thus, based on percentage degradation, Methyl acetoacetate is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for read across substance Methyl acetoacetate (CAS no. 105-45-3) (HSDB, 2016). The study was performed according to OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test). The percentage degradation of read across substance was determined to >90% degradation in 2 days. Thus, based on percentage degradation, Methyl acetoacetate is considered to be readily biodegradable in nature.
On the basis of above results for target chemical p-tolyl acetate(from gsbl authoritative database, OECD QSAR toolbox version 3.4 and EPI Suite) and for its read across substance (from authoritative database J-CHECK and HSDB), it can be concluded that the test substance p-tolyl acetate can be expected to be readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.