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EC number: 215-523-1 | CAS number: 1328-51-4 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 74180.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Reports of the Scientific Committee on Cosmetology (seventh series)
- Author:
- Commission of the European Communities
- Year:
- 1 988
- Bibliographic source:
- Directorate-General Environment, Consumer Protection and Nuclear Safety- Commission of the European Communities- Brussels Luxembourg, 1988.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The skin sensitization study of Pigment Blue 15 was conducted on guinea pigs to determine its sensitization potential.
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Pigment Blue 15
- IUPAC Name:
- Pigment Blue 15
- Reference substance name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- EC Number:
- 205-685-1
- EC Name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- Cas Number:
- 147-14-8
- Molecular formula:
- C32H16CuN8
- IUPAC Name:
- [29H,31H-phthalocyaninato(2-)-kappa~2~N~29~,N~31~]copper
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):Copper, (29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32)
- Molecular formula (if other than submission substance):32H16CuN8
- Molecular weight (if other than submission substance):578.0962 g/mol
- Smiles notation (if other than submission substance):c1ccc2=C3N=C4c5ccccc5C6=N4[Cu+2]78[N-]3C(=c2c1)N=C9N7=C(c1c9cccc1)N=C1[N-]8C(=N6)c2c1cccc2
- Substance type:Organic
- Physical state:no data
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Name of test material (as cited in study report):Copper, (29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32), Copper phthalocyanine
- Molecular formula :C32H16CuN8
- Molecular weight :578.0962 g/mol
- Smiles notation :c1ccc2=C3N=C4c5ccccc5C6=N4[Cu+2]78[N-]3C(=c2c1)N=C9N7=C(c1c9cccc1)N=C1[N-]8C(=N6)c2c1cccc2
- Substance type:Organic
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- water
- Concentration / amount:
- 1% aqueous solution(0.1mL)
- Day(s)/duration:
- 5 days
Challenge
- Route:
- other: epicutaneous
- Vehicle:
- water
- Concentration / amount:
- 1% aqueous solution(0.1mL)
- No. of animals per dose:
- no data
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:15
- Exposure period:5 days
- Test groups: guinea pigs
- Control group: no data
- Site: no data
- Frequency of applications: 3 times/day
- Duration: :5 days
- Concentrations: 1% aqueous solution(0.1mL)
B. CHALLENGE EXPOSURE
- No. of exposures:1
- Day(s) of challenge: after 4 weeks
- Exposure period: no data
- Test groups: guinea pigs
- Control group: no data
- Site: no data
- Concentrations: 1% aqueous solution(0.1mL)
- Evaluation (hr after challenge): no data
OTHER: - Challenge controls:
- no data
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 672
- Group:
- test chemical
- Dose level:
- 1% aqueous solution(0.1mL)
- No. with + reactions:
- 0
- Clinical observations:
- not sensitising
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
not specified
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Conclusions:
- The skin sensitization study of Pigment Blue 15 (CAS No: -147-14-8) was performed in guinea pigs to observed its sensitizing efficacy. The test material Pigment Blue 15 (CAS No: -147-14-8) was observed to be not sensitizing to guinea pigs.
- Executive summary:
The skin sensitization study of Pigment Blue 15 (CAS No: -147-14-8) was performed in guinea pigs to observed its sensitizing efficacy.
Guinea pigs were induced with intracutaneous injections of a 0.1 mL 1% aqueous solution 3 times/day for 5 days.
After 4 weeks, animals were topically challenged with 0.1 mL of 1% aqueous solution.
Since guinea pigs did not show any cutaneous reaction, the test materialPigment Blue 15 (CAS No: -147-14-8) was found to be non sensitizing.
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