Registration Dossier
Registration Dossier
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EC number: 613-313-8 | CAS number: 6368-20-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid
- EC Number:
- 613-313-8
- Cas Number:
- 6368-20-3
- Molecular formula:
- C8H15NO5
- IUPAC Name:
- (R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Controls:
- other: Other eye of the animal
- Duration of treatment / exposure:
- 0,1 g of test item were instilled into the conjunctival sac of one eye of each animal.
After an exposure period of 24h the treated eyes were rinsed with deionised water. - Observation period (in vivo):
- The conjunctivae, cornea and iris of the eyes were examined at 1, 24, 48 and 72 hours and from day 4 to day 21 after instillation.
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Score:
- >= 3
- Irritation parameter:
- iris score
- Score:
- ca. 2
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- H318 - Causes serious eye damage.
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