Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-09-13 to 2011-10-10
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.3
Temp.:
25 °C
Remarks on result:
other: no pH measurements
Remarks:
Mobile phase is neutral

Substance tR [min] k log k log Pow
Phenylacetonitrile  1.535 0.246 -0.609 0.84
Phenylacetonitrile 1.847 0.499 -0.302 1.56
Cinnamyl alcohol  1.689 0.371 -0.431 1.95
Nethyl benzoate  2.207 0.791 -0.102 2.2
Ethyl benzoate  2.624 1.13 0.053 2.64
Bromobenzene 3.079 1.499 0.176 2.99
Naphthalene 3.338 1.709 0.233 3.35
1,4-Dichlorobenzent  3.667 1.976 0.296 3.45
Biphenyl 4.063 2.298 0.361 3.98
Diphenyl ether  3.927 2.188 0.34 4.21
Test substance 3.168 1.571 0.196 3.3
Test substance 3.171 1.574 0.197 3.3
Conclusions:
The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.
Executive summary:

A Reverse phase HPLC study was performed according to Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004) to determine the partition coefficient of the test substance. The octanol/water partition coefficient of a test substance was computed by experimentally determining its capacity factor k and then calculation of the logPow. The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.

Description of key information

The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.3
at the temperature of:
25 °C

Additional information

A Reverse phase HPLC study was performed according to Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004) to determine the partition coefficient of the test substance. The octanol/water partition coefficient of a test substance was computed by experimentally determining its capacity factor k and then calculation of the logPow. The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.