Registration Dossier
Registration Dossier
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EC number: 201-662-5 | CAS number: 86-29-3
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
Additional information
Hydrolysis
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH) (Directive 92/69/EEC, C.7). Test chemical concentration used for the study was 18.4 mg/l. At the start, each assay was treated with argon (according to guideline) to ensure anaerobic conditions at that time. All test vessels were incubated in the dark. Analytical method involve the use of HPLC. The study was performed at pH of 4, 7 and 9 and temperature of 25°C, respectively. The half-life period of test chemical was determined to be 75 and 42days at pH 4.0 & 7 and temperature of 25°C. Thus, based on this, test chemical is considered to be hydrolytically stable.
In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 5, 7 and 9, respectively. The half-life period of test chemical was determined to be 44 days at pH 5.0 and test chemical was reported to be hydrolytically stable at pH 7 and 9, respectively.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 42 days to 75 days at pH 4, 5 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is considered to be hydrolytically stable.
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