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Diss Factsheets
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EC number: 277-040-2 | CAS number: 72927-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Details on sampling:
- None
- Vehicle:
- no
- Details on test solutions:
- Not available
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Not available
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not available
- Hardness:
- Not available
- Test temperature:
- Not available
- pH:
- Not available
- Dissolved oxygen:
- Not available
- Salinity:
- Not available
- Nominal and measured concentrations:
- 0, 0.01, 0.1, 1.0, 10 and 100 mg/L
- Details on test conditions:
- Not available
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Not available
- Results with reference substance (positive control):
- Not available
- Reported statistics and error estimates:
- Not available
- Validity criteria fulfilled:
- no
- Conclusions:
- EC50 in Daphnia magna at 48 h : >100 mg/L
- Executive summary:
EC50 in Daphnia magna at 48 h : >100 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
None - Analytical monitoring:
- not specified
- Details on sampling:
- None
- Vehicle:
- no
- Details on test solutions:
- Not available
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Not available
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not available
- Hardness:
- Not available
- Test temperature:
- Not available
- pH:
- Not available
- Dissolved oxygen:
- Not available
- Salinity:
- Not available
- Nominal and measured concentrations:
- Not available
- Details on test conditions:
- Not available
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Not available
- Results with reference substance (positive control):
- Not available
- Reported statistics and error estimates:
- Not available
- Validity criteria fulfilled:
- no
- Conclusions:
- EC50 in Daphnia magna at 48 h : >100 mg/L
- Executive summary:
EC50 in Daphnia magna at 48 h : >100 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is the meta-isomer of the dye Reactive Blue 049, where the sulphonate group is bound at the meta-position of the aminobenzene moiety. The source chemical is the reaction mass of both the meta-isomer and the para-isomer of Reactive Blue 049.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.
2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Blue 49 meta/para (CAS# 72214-18-7 / EC# 276-481-8)
Target: Reactive Blue 49 meta (CAS# 72927-99-2 / EC# 277-040-2)
3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.2 Melting point / freezing point - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- EC50 in Daphnia magna at 48 h : >100 mg/L (2 studies)
- Executive summary:
Two weight of evidence studies showed that the source substance does not have acute toxic effects on Daphnia magna up to 100 mg/L which leads to a 48h-EC50 greater than 100 mg/L. The structurally related target substance will show the same behaviour and therefore it can be anticipated that the 48h-EC50 will be >100 mg/L as well.
Referenceopen allclose all
None
None
Description of key information
The test item had no acute toxicity effects on Daphnia magna with an 48-hour EC50 > 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Two weight of evidence studies showed that the source substance does not have acute toxic effects on Daphnia magna up to 100 mg/L which leads to a 48h-EC50 greater than 100 mg/L. The structurally related target substance will show the same behaviour and therefore it can be anticipated that the 48h-EC50 will be >100 mg/L as well.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.