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EC number: 207-300-2 | CAS number: 460-00-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from National Toxicology Program (NTP)
- Justification for type of information:
- Data is from National Toxicology Program (NTP)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical in rats
- Author:
- National Toxicology Program (NTP)
- Year:
- 2 005
- Bibliographic source:
- National Toxicology Program (NTP)
- Reference Type:
- review article or handbook
- Title:
- Initial submission: Inhalation Median lethal concentration toxicity study with test chemical in Rats with cover letter
- Author:
- Haskell Laboratory
- Year:
- 1 986
- Bibliographic source:
- NTRL report No.88920004148
- Reference Type:
- secondary source
- Title:
- Provisional Peer Reviewed Toxicity Values for test chemical
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 017
- Bibliographic source:
- U.S. Environmental Protection Agency
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Acute inhalation toxicity study of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- other: Single dose study
- Limit test:
- no
Test material
- Reference substance name:
- 1-bromo-4-fluorobenzene
- EC Number:
- 207-300-2
- EC Name:
- 1-bromo-4-fluorobenzene
- Cas Number:
- 460-00-4
- Molecular formula:
- C6H4BrF
- IUPAC Name:
- 1-bromo-4-fluorobenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 4-Bromofluorobenzene (INY-1059-1)
- Molecular formula (if other than submission substance): C6H4BrF
- Molecular weight (if other than submission substance): 175.0 g/mole
- Substance type: Organic
- Physical state: Clear coloureless to slightly yellow liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Kingston, New york
- Age at study initiation: 8 weeks old
- Weight at study initiation: 221 to 258 gm
- Housing: Animals were housed in a pair suspended, stainless steel, wire –mash cages with dimensions of 8” X 14” X 8” (wXdXh). Each rat was assigned lower number in each cage, identification by a slash in the right ear. Prior to being exposed rats tails and cage cards were colore- coded with warter insoluble markersso that individual rats coul be identified after exposure.
- Diet (e.g. ad libitum): Purina certified rodent chow #5002, except during exposure, ad libitum
- Water (e.g. ad libitum): water, ad libitum
- Acclimation period: 1 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2 °C
- Humidity (%): 50 ± 10%
- Photoperiod (hrs dark / hrs light): Timer-controlled, 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 2/8/85
To: 2/28/85
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- VEHICLE
- Concentration in vehicle: 7.1, 14, 19, 22 and 26 mg/L
DOSAGE PREPARATION (if unusual): Vapor atmospheres of INY-1059-1 were generated by metering with syringe drive onto the inner surface of a heated, 3-neck round bottom flash evaporation. Dilution air was added to the flask to sweep the vapors into glass 38 liter exposure chamber. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 7.1, 14, 19, 22 and 26 mg/L
- No. of animals per sex per dose:
- Total : 50
7.1 mg/L bw: 10 male
14 mg/L bw: 10 male
19 mg/L bw: 10 male
22 mg/L bw: 10 male
26 mg/L bw: 10 male - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and body weight were examined. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 18 mg/L air
- Based on:
- test mat.
- 95% CL:
- > 15 - < 21
- Exp. duration:
- 4 h
- Remarks on result:
- other: No effect on survival, clinical and body weight
- Mortality:
- At 22 mg/L and 26 mg/L, 6 and 10 male rats were dead, 3 at 19 mg/L bw, 4 at 14 mg/L and no effect on survival of 7.1 mg/L treated rats were observed.
- Clinical signs:
- other: Loss of righting reflex, diminished startle response, lethargy, tremors, spasms, labored or rapid breathing, red nasal discharge, and darkened eyes were observed in treated rats.
- Body weight:
- Slight -to-moderate body weight loss (up to 8%) was observed in rats exposed to 7.1 mg/L and a slight-to-severe weight loss (4.1- 17.5%) was observed in the rats exposed to 14 mg/L or greater. were observed in treated rats.
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
Sr no. |
Dose rate |
Average body weight |
Emulsion concentration (mg/ml) |
Average dose |
Mortality ratio |
1 |
1000 |
231(227-243) |
225 |
1.0 |
0/10 |
2 |
2000 |
251(235-268) |
300 |
1.7 |
1/10 |
3 |
3000 |
242(226-253) |
300 |
2.4 |
7/10 |
4 |
5000 |
259(255-267) |
300 |
4.3 |
10/10 |
Sr no. |
Concentration mg/L |
Mortality |
||
|
Mean |
S.D |
Range |
Death/Exposed |
1 |
7.1 |
0.27 |
6.8-7.5 |
0/10 |
2 |
14 |
1.2 |
12-16 |
4/10 |
|
19 |
0.89 |
17-20 |
3/10 |
3 |
22 |
1.0 |
20-24 |
6/10 |
4 |
26 |
0.93 |
25-27 |
10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 18 mg/L bw (15 – 21 mg/L) when Crl:CD (SD)BR male rats were exposed to test chemical by nose only inhalation.
- Executive summary:
In acute inhalation toxicity study,Crl:CD (SD)BR male rats were treated with 4-Bromofluorobenzene (4-BFB) in the concentration of 7.1, 14, 19, 22 and 26 mg/L in air generated by metering with syringe drive onto the inner surface of a heated, 3-neck round bottom flash evaporation. Dilution air was added to the flask to sweep the vapors into glass 38 liter exposure chamber and observed for 14 days. 6 and 10 male rats were dead at 22 mg/L and 26 mg/L, 3 at 19 mg/L bw, 4 at 14 mg/L and no effect on survival of 7.1 mg/L treated rats were observed. Loss of righting reflex, diminished startle response, lethargy, tremors, spasms, labored or rapid breathing, dry red nasal discharge,incrased salivation,red ocular discharge,lung noise, darkened eyes,partially closed eyes, ruffled and discolored fur were observed in treated rats. Slight -to-moderate body weight loss (up to 8%) was observed in rats exposed to 7.1 mg/L and a slight-to-severe weight loss (4.1- 17.5%) was observed in the rats exposed to 14 mg/L or greater were observed in treated rats. Therefore, LD50 value was considered to be 18 mg/L bw in air(15 – 21 mg/L),when Crl:CD (SD)BR male rats were exposed to 4-Bromofluorobenzene (INY-1059-1)(460 -00 -4) by nose only inhalation.
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