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Diss Factsheets
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EC number: 204-255-0 | CAS number: 118-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral
subacute: 5 day, rat, increasing doses from 200 to 1013 mg/kg bw/d: No NOAEL identifiable; no mortality, no clinical signs (standardized protocol, according to Lim et al. 1961; BAYER 1970)
inhalation
subacute: 28 day, rat, aerosol: systemic NOEL = 0.0116 mg/L (increased lung and liver weights in the higher dosed females; standardized protocol, according to Niessen et al. 1963; BAYER 1970)
subacute: 5 day, rat, aerosol: No NOAEL identifiable (standardized protocol, according to Niessen et al. 1963; BAYER 1970)
Key value for chemical safety assessment
Additional information
oral
An accumulation test was performed in accordance to Lim et al. (1961). Following a standardized protocol, 30 male Wistar rats received increasing doses of the test substance (technical grade) in an aceton/oil 1:10 preparation for five days per gavage, starting with 200 mg/kg bw up to 1013 mg/kg bw on day 5. A recovery period of seven days followed the treatment period. No deaths and no clinical signs of toxicity were observed at any time point. Due to missing test parameters no NOAEL was identified (BAYER 1970).
Inhalation
An subacute dynamic inhalation study was performed in accordance to Niessen et al. (1963) following a standardized protocol. 10 male and 10 female Wistar rats were exposed to an aerosol of 0.0116 or 0.071 mg/L test substance (technical grade; analytical concentration), which was prepared in a DMSO/ Lutrol 1:1 solution, for 4 hours per day, 5 days per week for four weeks. A control group was exposed to the concurrent vehicle, (DMSO/ Lutrol, 1:1). Observations/examinations included behaviour, body weight gain, selected hematological and clinical-chemical parameters, organ weights and gross pathology.
In high dose females, absolute and relative lung weights and relative liver weights were statistically increased. No other changes were noted. A histopathological examination and a recovery period were not carried out. Therefore, the adversity of the effects - and subsequently an adverse effect level - can not be assessed. The NOEL, however, was carefully considered to be 0.0116 mg/L (BAYER 1970).
Another study was performed following the same study design for only 5 days. Here, 10 Wistar rats of both sexes were exposed to an aerosol with a analytical concentration of 0.197 mg/L (corresponding to 1 mg/L nominal conc.). Neither mortality nor clinical signs were observed. Due to missing test parameters no NOAEL was identified (BAYER 1970).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.