Registration Dossier
Registration Dossier
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EC number: 612-182-4 | CAS number: 6161-65-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to guideline, but non-GLP. Only short summary available. However, sufficient for robust study summary.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-Methoxy-6-methylbenzoic acid
- EC Number:
- 612-182-4
- Cas Number:
- 6161-65-5
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 2-Methoxy-6-methylbenzoic acid
- Details on test material:
- - charge: 30529/006
- substance name: BAS 560F -(Benzoe-)Säure
- substance number: 01/0246-1
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - application volume: 10 mL/kg
- concentration: 20 g/100 mL - Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- Poor general state, dyspnoe, apathy, staggering, ataxie, piloerection, exophthalmus, cramped position.
- Gross pathology:
- no findings
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study, the test substance does not need to be classified for acute oral toxicity, according to Regulation (EC) No. 1272/2008 and Directive 67/548/EEC.
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