Isopentyl oleate

Endpoint summary

Additional information

Data on the aquatic toxicity of Isopentyl oleate (CAS 627-89-4) are not available.
In accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across to the structurally related substances Isopropyl oleate (CAS 112-11-8) and Isobutyl oleate (CAS 84988-79-4) was conducted to fulfil the standard information requirements. In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across). According to Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 substances can be considered to be similar if their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.

Isopentyl oleate (CAS 627-89-4) is an UVCB substance comprising saturated and unsaturated linear C16-C18 fatty acids esterified with a branched C5 alcohol. The source substance Isobutyl oleate (CAS 84988-79-4), is a branched C4 alcohol esterified with a linear C14-C18 linear saturated and unsaturated fatty acid chains. Whereas Isopropyl oleate (CAS 112-11-8) is a branched C3 alcohol esterified with saturated and unsaturated linear C14-C18 fatty acid chains. The read across substances cover the alcohol moiety as well as the longest and shortest fatty acid chains of the target substance.

The target and the source substances are characterised by a low water solubility, low vapour pressure and comparable log Koc values. Thus, the substances are expected to have a similar environmental fate and ecotoxicity profile.

In accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5, grouping and read-across the target substance Isopentyl oleate (CAS 627-89-4) is not considered to be harmful to aquatic organisms based on the results of the available read across studies conducted with fish, aquatic invertebrates and algae and long-term results on toxicity to aquatic invertebrates.

Experimental data on the acute toxicity of the read-across substance Isopropyl oleate (CAS 112-11-8) are available for fish and aquatic invertebrates. No toxicity of the substance was determined up to the limit of water solubility. Comparable results were obtained in the acute toxicity test on the read-across substance Isobutyl oleate (CAS 84988-79-4). The studies determined no adverse effects on fish, aquatic invertebrates and algae up to the limit of water solubility.

Data on chronic toxicity are available for the read-across substance Isobutyl oleate (CAS 84988-79-4). The long-term toxicity of the substance to Daphnia magna was tested. An effect on survival and reproduction rate of the daphnids was not observed up to the limit of water solubility (NOELR (21 d) ≥ 100 mg/L).

Data on the toxicity to microorganisms are available for the read-across substance Isopropyl oleate (CAS 112-11-8). Adverse effects of the substances to microorganisms were not observed.

The available acute and chronic toxicity data of the read-across substances demonstrate that toxic effects of the target substance Isopentyl oleate (CAS 627-89-4) up to the limit of water solubility are not likely. Consequently, additional acute and chronic testing is omitted. Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Isopentyl oleate (CAS 627-89-4) will not show toxic effects on freshwater organisms up to the limit of the water solubility (WS < 3 µg/L at 20 °C).