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Diss Factsheets
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EC number: 700-163-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
At low non irritating concentrations, the substance may be absorbed after oral exposure, metabolised in the liver (via the CYP), may be distributed as metabolites entering the bloodstream and finally excreted mainly in the urine.
Considering the substance low vapour pressure (no volatilisation), exposure by inhalation to the substance is unlikely to occur.
Short description of key information on absorption rate:
The substance may be dermal absorbed.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
At low non irritating concentrations, the substance may be absorbed after oral exposure, metabolised in the liver (via the CYP), may be distributed as metabolites entering the bloodstream and finally excreted mainly in the urine.
Considering the substance low vapour pressure (no volatilisation), exposure by inhalation to the substance is unlikely to occur.
As water soluble surface active liquid, the substance may be absorbed during dermal exposure.
Discussion on bioaccumulation potential result:
The substance is a corrosive liquid with a middle molecular weight of 293.49 g/mol. Moreover, it is water soluble (see § 4). Therefore, the substance is an amphiphilic substance for which the gastro-intestinal absorption may occur by the ability of the substance to dissolve into the gastro-intestinal fluids after oral exposure and hence make contact with the mucosal surface. However, this contact is limited by the corrosive properties of the substance which can induce membrane destruction according to the concentrations. However, at low non irritating concentrations, the substance may be absorbed after oral exposure, mainly undergo liver cytochrome P450 dependent N-hydroxylation. Metabolites are likely distributed throughout the tissues entering the bloodstream and then mainly excreted in the urine. Finally, acute toxicity study and 28 -day repeated dose toxicity study performed in rats with the substance administered by oral route didn't show any systemic effect at 50 mg/kg bw and 30 mg/kg bw/d respectively (see § 7.2 and § 7.5) .
The substance is a liquid with low vapour pressure inducing no significant volatilization under environmental conditions. Hence, exposure by inhalation is unlikely to occur.
Discussion on absorption rate:
The substance is a water soluble liquid at ambient temperature with corrosive properties (pH > 12). As the substance exhibits both hydrophobic and hydrophilic moities, dermal absorption may occur. In fact, considering both its middle molecular weight (293.49 g/mol) and the compound hydrophobic part, uptake into the stratum corneum itself may be rapid after skin contact at low non-irritating concentrations. Then, taking into account its water solubility, the substance partitions from the stratum into the epidermis may occur followed by diffusion into the dermis which contains blood capillaries. Following systemic absorption, the substance may be excreted by the kidney in the urine considering its water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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