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EC number: 278-154-5 | CAS number: 75268-65-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 January 1993 to 13 March 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 4 April 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- February 1990
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Code number: FAT 40138/D
Batch No.: 275605.26
Purity: 79 %
Appearance: solid
Color: yellow
Solubility: 100 g/l [in water]
Storage: at room temperature
Expiration date: July, 1993 - Analytical monitoring:
- yes
- Details on sampling:
- For the analytical measurements of the test substance concentrations duplicate samples from the freshly prepared test solution and the control were taken at the start of the test. For the determination of the stability of the test substance under test conditions, samples from the test media were collected at the end of the test (after 48 hours). The concentration of the test substance FAT 40138/D was analysed in singular in the control samples and in the duplicate test media samples from the nominal test concentration of 1000 mg/l at both sampling dates (0 and 48 hours). All samples are kept stored at -20 °C to enable additional analyses.
- Vehicle:
- no
- Details on test solutions:
- The test substance was weighed and directly dissolved in the test water just before introduction of daphnids ( = start of the test). The only nominal concentration tested was 1000 mg test substance/l and a control (test water without any additions).
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: RCC (testing laboratory)
The study has been performed with young daphnids (at the start of the test 6 - 24 hours old) of a clone of the species Daphnia magna Straus. The clone was bred in the laboratories of RCC under standardized conditions. The cultivation of the parental daphnids was performed in reconstituted water of a similar quality regarding to pH, components of the main ions and total hardness as the test water used in the test. - Test type:
- static
- Water media type:
- not specified
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/l CaCO3
- Test temperature:
- 19.4 - 20.0 °C
- pH:
- 7.7 - 7.9
- Dissolved oxygen:
- 9.2 mg/l or higher
- Nominal and measured concentrations:
- 1000 mg test article/l (nominal concentration);
- Details on test conditions:
- Experimental conditions:
In the test concentration and control 20 daphnids were tested, divided into four groups of five animals, each group in 50 ml test medium in a glass-beaker (100 ml). The daphnids were not fed during the test period. The test was performed in an air-conditioned room.
Water temperature: 19.4 - 20.0 °C during test period.
Light: 16 hours per day, approximately 200 - 600 Lux
Test duration: 48 hours
Test water: reconstituted water: in deionized water with a conductivity lower than 0.1 µS cm-1 analytical grade salts were dissolved and the water was aerated to saturation. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The measured test substance concentrations in the test solution amounted to 103.9 %, respectively, 104.9 % of the nominal value. The test substance was sufficiently stable under test conditions during the test period. Therefore, the reported results are related to the nominal concentrations of the test substance. No immobility or mortality was observed in the control and in the test solution of 1000 mg test solution/l during the test.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 h EC50 of FAT 40138/D in the acute toxicity to daphnia was calculated as >1000 mg/l.
- Executive summary:
The acute toxicity of FAT 40138/D to Daphnia magna was determined in a 48 hours static test according to the OECD Guideline 202 and EU Method C.2. Based on the results of a pretest the nominal concentration for the main test was selected as 1000 mg test article/l.
No immobility or mortality was observed in the control and in the test solution of 1000 mg test solution/l during the test. Thus, the NOEC and EC0 value after 48 hours were determined to be 1000 mg/l. The EC50 value after 48 hours was determined as >1000 mg/l.
Reference
Description of key information
The EC50 value after 48 hours was determined as >1000 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 000 mg/L
Additional information
In a key study, the acute toxicity of FAT 40138/D to Daphnia magna was determined in a 48-hours static test according to the OECD Guideline 202 and EU Method C.2. Based on the results of a pretest the nominal concentration for the main test was selected as 1000 mg test article/l. No immobility or mortality was observed in the control and in the test solution of 1000 mg test solution/l during the test. Thus, the 48 h NOEC and EC0 value were determined to be 1000 mg/l. The EC50 value after 48 hours was determined as >1000 mg/l.
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