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EC number: 406-640-0 | CAS number: 136920-07-5 KEROFLUX ES 3241
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- aim of the study was to check whether EDTA can be formed from Keroflux ES 3241 under in vitro conditions (0.1 M HC1, rat plasma or rat liver homogenate).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- Batch No.: (T 75492/ST 1414/90) Partie 1
Manufacturing/Sampling Date: 10.10.1990
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: in vitro study
- Strain:
- other: in vitro study
Administration / exposure
- Route of administration:
- other: in vitro study
- Vehicle:
- other: in vitro study
- Details on exposure:
- in vitro incubation and sample preparation: The test substance (1 mg/ml) was incubated in 0.1 M HCl, rat plasma and rat liver homogenate at 37°C for 4 hours. Samples were drawn immediately after addition of the test substance to the incubation medium (0 h) and after 1, 2 and 4 hours. The samples were extracted twice with n-hexane. Combined hexane phases were used for Keroflux ES 3241 analyses. Aqueous phases were acidified with 1 M acetic acid and centrifuged. After addition of a FeCl3-solution to the supernatant, this solution was taken for EDTA-analyses.
- Duration and frequency of treatment / exposure:
- up to 4 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Concentrations for incubation periods of 0, 1, 2 and 4 h, respectively:
Incubation in 0.1 M HCl: 1.03, 1.1, 1.13, 0.97 mg/ml
Incubation in rat plasma: 0.7, 0.8, 0.6, 0.53 mg/ml
Incubation in rat liver homogenate: 0.93, 0,97, 1.17, 0.87 mg/ml
- No. of animals per sex per dose / concentration:
- in vitro study, number of replicates not reported
- Control animals:
- other: in vitro study
Results and discussion
Any other information on results incl. tables
Incubation of Keroflux ES 3241 in 0.1 M HCl 1 mg/ml at 37°C for up to 4 hours simulating conditions in the stomach lead to a small decrease of Keroflux ES 3241 concentration in the incubation medium (maximum 6% after 4 hrs of incubation). With respect to the variation of the results at 1 and 2 h, this decrease is not significant. No EDTA could be detected considering a detection limit of about 2 µg/ml.
Incubation of Keroflux ES 3241 in rat plasma at 37°C for up to 4 hours lead to a decrease of Keroflux ES 3241 concentration in the incubation medium by 24 % after 4 hrs of incubation (10% after 2 hrs of incubation). However, no EDTA could be detected above a detection limit of about 2 µg/ml.
Incubation of Keroflux ES 3241 in rat liver homogenate at 37°C for up to 4 hours lead to a small decrease of Keroflux ES 3241 concentration in the incubation medium (maximum 6% after 4 hrs of incubation). With respect to the variation of the results at 1 and 2 h, this decrease is not significant. No EDTA could be detected considering a limit of detection of about 6 µg/ml.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.