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EC number: 436-900-9 | CAS number: 39290-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Amest test
Mutagenic activity of Terracess P was tested in the first mutation assay at a concentration range of 33 to 3330 µg/plate in the absence and presence of 5% (v/v) S9 -mix in tester strains TA1535, TA1537, TA98. In an independent repeat of the assay with additional parameters, Terracess P was tested at the same concentration range as the first assay in the absence and presence of 10% (v/v) S9-mix in tester strains TA1535, TA1537, TA98, TA100 and WP2uvrA. Precipitation was observed at 3330 μg/ml. Terracess P did not induce a significant dose-related increase in the number of revertant (His+) colonies in each of the four tester strains (TA1535, TA1537, TA98 and TA100) and in the number of revertant (Trp+) colonies in tester strain WP2uvrA both in the absence and presence of S9-metabolic activation. These results were confirmed in an independently repeated experiment. Based on the results of this study it is concluded that Terracess P is not mutagenic in the Salmonella typhimurium reverse mutation assay and in the Escherichia coli reverse mutation assay.
Chromosome aberration test
Terracess P was for the ability to induce chromosome aberrations in cultured human lymphocytes up to 100 µg/ml for a 3h exposure time with a 24 h fixation time in the absence and presence of 1.8% (v/v) S9 -fraction. In the second cytogenetic assay, Terracess P was tested up to 100 µg/ml for a 24 h and 48 h continuous exposure time with a 24 h and 48 h fixation time in the absence of S9-mix. In the presence of S9-mix Terracess P was also tested up to 100 µg/mL for a 3 h exposure time with a 48 h fixation time. Terracess P did not induce a statistically significant or biologically relevant increase in the number of cells with chromosome aberrations in the absence and presence of S9-mix, in two independently repeated experiments. Therefore it can be concluded that Terracess P is not clastogenic in human lymphocytes under the experimental conditions described.
MLA assay
Terracess P was tested up to concentrations of 100 μg/ml (dose range finding test) and 33 μg/ml in the absence and presence of 8% (v/v) S9 -mix with a 3 h incubation time in the first experiment. In the second experiment,
Terracess P was again tested up to concentrations of 33 µg/mL but in the absence and presence of 12% (v/v) S9 -mix. Incubation times were 24 and 3 hours in the absence and presence of S9 -mix, respectively. No toxicity was observed, but at the highest dose levels precipitation occurred. In the presence and absence of S9-mix, Terracess P did not induce a significant increase in the mutation frequency in the presence and absence of S9 -mix, in the first experiment and confirmed in the independent repeat experiment. It is concluded that Terracess P is not mutagenic in the mouse lymphoma L5178Y test system under the experimental conditions described.Short description of key information:
Negative in the Ames test (EC B13/14/OECD 471)
Negative in the in vitro mammalian chromosome aberration test (EC B.10/OECD 473)
Negative in the in vitro mammalian gene mutation test (EC B.7/OECD 476)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available studies, Terracess P does not have to be classified for mutagenicity according to Directive 67/548/EEC and CLP Regulation EC (No.) 1272/2008.
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