Registration Dossier
Registration Dossier
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EC number: 620-213-8 | CAS number: 2892-29-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 92/69 EEC B.5
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-(3-Chloro-4-hydroxyphenyl)ethanone
- Cas Number:
- 2892-29-7
- Molecular formula:
- C8 H7 Cl O2
- IUPAC Name:
- 1-(3-Chloro-4-hydroxyphenyl)ethanone
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Wistar
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1g
- Observation period (in vivo):
- 72 hours - 10 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- animals #1 #2 #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animals #1, #2, #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- animals #1, #2, #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 1 - <= 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animals #1, #2, #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0.33 - <= 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- other: discharge
- Basis:
- mean
- Remarks:
- animals #1, #2, #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- changes fully reversible within 8 days (animal 1), 10 days (animal 2), 7 days (animal 3).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- the substance produced irritating effects, which were reversible, but no corrosion.
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