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EC number: 918-906-8 | CAS number: 65684-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 - 14 May 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Limited data on animal husbandry, six animals were used, no anasthetics were used, the test substance purity was not specified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted Oct 2012
- Deviations:
- yes
- Remarks:
- limited data on animal husbandry, six animals were used, no anasthetics were used, the test substance purity was not specified.
- Qualifier:
- according to guideline
- Guideline:
- other: Official method of the French Republic published in 'Journal Officiel' 21 Feb 1982 and 24 Oct 1984
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): undecylenate de glycerol
- Physical state: white congealed paste
- Analytical purity: no data
- Lot/batch No.: 1007C
- Storage condition of test material: at room temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: COB.LABO.LAP, Yffiniac, France
- Weight at study initiation: approximately 2.1 kg
- Housing: animals were housed individually
- Acclimation period: 3 weeks
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 7 days
Reading time points: 1, 24, 48 and 72 h, and day 4 and 7 (mean values only given for day 7) - Number of animals or in vitro replicates:
- 6 males
- Details on study design:
- SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 4 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- One hour after instillation of the test substance, 6/6 rabbits had obvious swelling (chemosis score 2) and 1/6 rabbits had some conjunctivae (score 1). At the 24-hour reading time point, chemosis (score 1-2) was observed in 6/6 animals. The chemosis gradually reduced in severity, persisting in 4/6 at the 48-hour reading time point, in 3/6 at the 72-hour reading time point, and in 1/6 until 4 days after instillation. No conjunctivae was observed in any animal from 24 hours after instillation. No irritation effects were seen on the iris and cornea in any animal at any reading time point. Only mean values were given for Day 7, and it is therefore not possible to determine if the irritation effects had cleared by Day 7.
Any other information on results incl. tables
Table 1. Eye irritation scores
Rabbit #
|
Time
|
conjunctivae
|
iris
|
cornea
|
|
redness |
swelling |
||||
1
|
1 h |
0 |
2 |
0 |
0 |
24 h |
0 |
2 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h 4 d |
0 0 |
0 0 |
0 0 |
0 0 |
|
Average* |
0.0 |
0.67 |
0.0 |
0.0 |
|
2
|
1 h |
0 |
2 |
0 |
0 |
24 h |
0 |
2 |
0 |
0 |
|
48 h |
0 |
2 |
0 |
0 |
|
72 h 4 d |
0 0 |
1 0 |
0 0 |
0 0 |
|
Average* |
0.0 |
1.67 |
0.0 |
0.0 |
|
3
|
1 h |
0 |
2 |
0 |
0 |
24 h |
0 |
2 |
0 |
0 |
|
48 h |
0 |
1 |
0 |
0 |
|
72 h 4 d |
0 0 |
0 0 |
0 0 |
0 0 |
|
Average* |
0.0 |
1.0 |
0.0 |
0.0 |
|
4
|
1 h |
0 |
2 |
0 |
0 |
24 h |
0 |
1 |
0 |
0 |
|
48 h |
0 |
1 |
0 |
0 |
|
72 h 4 d |
0 0 |
1 1 |
0 0 |
0 0 |
|
Average* |
0.0 |
1.0 |
0.0 |
0.0 |
|
5
|
1 h |
1 |
2 |
0 |
0 |
24 h |
0 |
1 |
0 |
0 |
|
48 h |
0 |
1 |
0 |
0 |
|
72 h 4 d |
0 0 |
1 0 |
0 0 |
0 0 |
|
Average* |
0.0 |
1.0 |
0.0 |
0.0 |
|
6
|
1 h |
0 |
2 |
0 |
0 |
24 h |
0 |
2 |
0 |
0 |
|
48 h |
0 |
0 |
0 |
0 |
|
72 h 4 d |
0 0 |
0 0 |
0 0 |
0 0 |
|
Average* |
0.0 |
0.67 |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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