Registration Dossier
Registration Dossier
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EC number: 224-208-8 | CAS number: 4247-02-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 64% (CO2 evolution) in 18 days (OECD 301B) based on read-across to butyl 4-hydroxybenzoate (CAS 94-26-8).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
No studies investigating the ready biodegradation of isobutyl 4-hydroxybenzoate (CAS No. 4247-02-3) are available. Therefore, biodegradation data for butyl 4-hydroxybenzoate (CAS 94-26-8) are used as read across. This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as explained within the analogue justification in IUCLID section 13.
The key study was conducted according to OECD 301B and GLP standards (Noack, 2004). Non adapted activated sludge was used as inoculum. The concentration of the test item and the theoretical CO2 production (ThCO2) were calculated based on the determined carbon content of the test item. The percentage degradation of the functional control reached the pass level of 60% after 8 days. In the toxicity control containing both test and reference item a biodegradation rate of 77% occurred within 14 days and came to a maximum of 100 % after 28 days. The biodegradation of the reference item was not inhibited by the test item in the toxicity control. For the test item the 10% level (beginning of biodegradation) was reached after an adaptation phase of 3 days and in the 10d window a mean biodegradation of 61% was reached. The mean maximum biodegradation came to 64% after 18 days. At this point of time the plateau was reached. Thus, the test item is considered readily biodegradable according to the stringent requirements of the OECD 301B guideline.
Consequently, based on the read-across conducted, the target substance isobutyl 4-hydroxybenzoate (CAS No. 4247-02-3) is considered readily biodegradable.
[Type of water: freshwater]
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