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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1994
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Study of Lithium Absorption by Users of Spas Treated with Lithium Ion
Author:
McCarty J.D. et al
Year:
1994
Bibliographic source:
Human and Experimental Toxicology May 1994 vol. 13 no. 5 315-319

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Lithium ion
IUPAC Name:
Lithium ion
Radiolabelling:
no

Test animals

Species:
other: human
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
other: spa bathing water at 101 ± 2 °F
Vehicle:
water
Duration of exposure:
20 minutes per day, 4 days a week for two consecutive weeks
Doses:
approximately 40 mg lithium ion / L
Control animals:
yes
Details on study design:
Control spa: 0.02 mg lithium ion / L

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
no effects
Absorption in different matrices:
At all stages of the 2 week exposure, there was no statistically significant difference in the serum lithium levels of the test and control groups

Applicant's summary and conclusion

Conclusions:
Exposure to lithium via the skin, does not cause an increase in serum lithium levels.
Executive summary:

The lithium ion is unlikely to penetrate the skin as no significant difference in serum lithium levels was observed between healthy volunteers exposed to 40 mg lithium ion / L in spa water for 20 minutes per day, 4 days per week for two consecutive weeks, when compared to controls exposed to spa water containing to 0.02 mg lithium ion / L for the same time period.