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Diss Factsheets
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EC number: 203-643-7 | CAS number: 109-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The substance shows mild to moderate acute toxicity by the oral, dermal and inhalation routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 950 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 10 100 mg/m³ air
- Quality of whole database:
- adequate
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 316 mg/kg bw
- Quality of whole database:
- adequate
Additional information
The acute oral toxicity in rats (LD50) of 2 -methylpyridine was 810 mg/kg bw in one study, and over 950 mg/kg bw in another study. The acute dermal toxicity (LD50 value) in rabbits of 2 -methylpyridine was between 200 and 316 mg/kg in one study, and was 387 mg/kg in another. The inhalation toxicity in rats (LC50) was over 9.4 mg/L (9400 mg/m3) in one study, but less than 13.2 mg/L in a second study. A third study showed a LC50 over 7618 mg/m3 or 7.6 mg/L (2000 ppm) but less than 15 mg/L (4000 ppm). A point value of just over 10 mg/L (10.1 mg/L, or 10100 mg/m3) is arbitrarily chosen within the boundaries of the studies provided.
Justification for selection of acute toxicity – oral endpoint
experimental data
Justification for selection of acute toxicity – inhalation endpoint
experimental data
Justification for selection of acute toxicity – dermal endpoint
experimental study
Justification for classification or non-classification
2 -Methylpyridine has a harmonized classification in Regulation (EC) No. 1272/2008, Index No. 613 -036 -00 -2 as Acute Category 4 (oral), Acute Category 4 (dermal) and Acute Category 4 (inhalation). These endpoints have an asterisk, and so must be considered minimum classifications. According to the data reviewed for the REACH assessment, 2 -Methylpyridine would be classified as Acute Category 4 (oral), where the LD50 of 950 mg/kg bw falls between 300 and 2000 mg/kg bw, and as Acute Category 3 (dermal) with the LD50 of 316 -384 mg/kg bw falling between 200 and 1000 mg/kg bw. For inhalation toxicity, the data in the three studies spans the boundary between Category 3 (500 < LC50 < 2500 ppm OR 0.5 < LC50 < 2.0 mg/L) and Category 4 (2500 < LC50 < 20,000 ppm OR 10 < LC50 < 20 mg/L). It is most likely that the LD50 is over 2500 ppm or 10 mg/L, and so the substance is classified as Category 4. There is insufficient data to support a change in the harmonized classification, from Category 4. Additionally, a STOT-SE Category 3 (H335) classification for respiratory irritation is included in the harmonized version. Considering the assignment of the substance to acute inhalation toxicity Category 4 and with a respiratory corrosion EUH071 hazard, STOT-SE Category 3 represents over-classification for the endpoint of inhalation toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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