Registration Dossier
Registration Dossier
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EC number: 265-741-6 | CAS number: 65405-70-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1969
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: experimental details lacking; however, followed accepted methodology at time of testing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test has been conducted prior to the current OECD guideline however, the LD50 calculation was based on an accepted method (Miller and Tainter).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (E)-4-decenal
- EC Number:
- 265-741-6
- EC Name:
- (E)-4-decenal
- Cas Number:
- 65405-70-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (E)-4-decenal
- Test material form:
- other: liquid
- Details on test material:
- Material: GIV 3-1094 (Decenal trans)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The animals were fasted 12 hours prior to dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Oral intubation
- Doses:
- 100, 316, 1000, 3160, 5000 and 10000 mg/Kg
- No. of animals per sex per dose:
- 6 groups of 6 animals (1 dose/animal)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 7 000
- Based on:
- test mat.
- Remarks on result:
- other: as calculated by method of Miller and Tainter
- Other findings:
- principle toxic effect: Sedation
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on this test the LD50 was determined to be 7000 mg/kg bw.
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