1-dodecylpyridinium chloride

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on three hydrolysis studies as-
2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Remarks:

2. The study was performed at pH range 5-9, respectively.

Temp.:

20 °C

Remarks:

3. The study was performed at pH 4, 7 and 9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

DT50:

> 150 - < 183 d

Remarks on result:

other: 2. at pH 5-7

pH:

9

DT50:

379 d

Remarks on result:

other: 2. Other details not known

Temp.:

20 °C

DT50:

>= 1 yr

Remarks on result:

other: 3. The study was performed at pH 4, 7 and 9, respectively.

Details on results:

2. The half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions over pH range 5-9, respectively.
3. The half-life period of test chemical was determined to be ≥ 1 yr at pH 4, 7 and 9, respectively and at a temperature of 20°C. Thus, test chemical was reported to be hydrolytically stable.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 150 days to ≥ 1 yr, at pH range 4-9 and at a temperature of 20°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be not hydrolysable in water.

Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life value of test chemical was determined at a pH range 5-9, respectively. The estimated half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 4, 7 and 9, & at a temperature of 20°C, respectively. The half-life period of test chemical was determined to be ≥ 1 yr at pH 4, 7 and 9, respectively & at a temperature of 20°C and thus test chemical was reported to be hydrolytically stable. On the basis of this, test chemical is considered to be not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 150 days to  ≥  1 yr, at pH range 4-9 and at a temperature of 20°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 150 days to ≥ 1 yr, at pH range 4-9 and at a temperature of 20°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be not hydrolysable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:

150 d

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life value of test chemical was determined at a pH range 5-9, respectively. The estimated half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed at pH of 4, 7 and 9, & at a temperature of 20°C, respectively. The half-life period of test chemical was determined to be ≥ 1 yr at pH 4, 7 and 9, respectively & at a temperature of 20°C and thus test chemical was reported to be hydrolytically stable. On the basis of this, test chemical is considered to be not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 150 days to  ≥  1 yr, at pH range 4-9 and at a temperature of 20°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be not hydrolysable in water.