Registration Dossier
Registration Dossier
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EC number: 201-642-6 | CAS number: 85-91-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on fragrance materials
- Author:
- Opdyke, D. L. J.
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmet. Toxicol., 13, 791, 1975
- Reference Type:
- secondary source
- Title:
- Opinion on Methyl-N-methylanthranilate (Phototoxicity only)
- Author:
- Scientific Committee on Consumer Safety
- Year:
- 2 011
- Bibliographic source:
- European Commission, Scientific Committee on Consumer Safety, 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of Dimethyl Anthranilate in larvae
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Methyl N-methylanthranilate
- EC Number:
- 201-642-6
- EC Name:
- Methyl N-methylanthranilate
- Cas Number:
- 85-91-6
- Molecular formula:
- C9H11NO2
- IUPAC Name:
- methyl 2-(methylamino)benzoate
- Details on test material:
- - Name of test material (as cited in study report): Dimethyl Anthranilate
- Molecular formula (if other than submission substance): C9H11NO2
- Molecular weight (if other than submission substance): 165.191 g/mole
- Substance type: Organic
Constituent 1
Test animals
- Species:
- other: Tribolium destructor
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data available
- Analytical verification of test atmosphere concentrations:
- not specified
- Concentrations:
- 115.1 mg/L
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 115.1 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed in exposed larvae of Tribolium destructor.
- Clinical signs:
- other: No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LC50 was considered to be 115.1 mg/L when larvae of Tribolium destructor inhaled by Dimethyl Anthranilate
- Executive summary:
In a acute inhalation toxicity study,larvae of Tribolium destructor were inhaled by Dimethyl Anthranilate in the concentration of 115.1 mg/L.50 % mortality was observed in exposed larvae of Tribolium destructor at115.1 mg/L. Therefore, LC50 was considered to be115.1 mg/L when larvae ofTribolium destructor inhaled by Dimethyl Anthranilate.
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