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Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Link to relevant study record(s)

Description of key information

ISO 14593, OECD 310, GLP, key study, validity 1:
78.56% biodegradation after 28 days, satisfied the 10 day window validation criterion.
Readily biodegradable

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

One key study is available to investigate the ready biodegradability of the registered substance when exposed to sewage sludge micro-organisms under aerobic conditions. The method followed the recommendations of ISO Guideline 14593 and of the OECD Guideline 310, with GLP statement.

The test substance, at a concentration of 20.00 mg C/L, was exposed to activated sewage sludge micro-organisms (4 mg/L dry weight activated sludge) with culture medium in sealed culture vessels in diffused light at 23 +/- 2°C for 28 days.

The degradation of the test substance was assessed by the determination of carbon dioxide produced on Days 0, 3, 7, 10, 14, 17, 21, 24 and 28. Control solutions with inoculum and the reference substance, sodium benzoate, together with a toxicity control, were used for validation purposes:

- The toxicity test attained 87.03% degradation after 28 days, thereby confirming that the test substance was not toxic to the sewage treatment micro-organisms used in the study.

- Sodium benzoate attained 93.67% degradation after 28 days, thereby confirming the suitability of the inoculum and test conditions.

The test substance attained 78.56% degradation after 28 days and satisfied the 10 day window validation criterion. Therefore the test substance can be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline 310.