7-benzamido-4-hydroxynaphthalene-2-sulphonic acid

Endpoint summary

Description of key information

Short term toxicity to fish:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6)on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 441.10 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the substance7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6)can be considered to be non toxic to aquatic environment and thus it become not classified as per the CLP classification criteria.

Short term toxicity to aquatic invertebrates:

Prediction based on the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6). EC50 value was estimated to be 840.24 mg/l for Daphnia magna for 48 hrs duration. Based on this value it can be considered that the 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) can be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Toxicity to aquatic algae:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6). EC50 value was estimated to be 140.02mg/l for Desmodesmus subspicatus for 72 h duration. Based on this value the 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) can be considered as non-toxic to aquatic environment and can be considered as not classified as per the CLP classification regulations.

Additional information

Short term toxicity to fish:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6)on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 441.10 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the substance7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6)can be considered to be non toxic to aquatic environment and thus it become not classified as per the CLP classification criteria.

Short term toxicity to aquatic invertebrates:

Short term toxicity to aquatic invertebrates for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) was summaries with predicted data for target and by using functional read across studies as follows:

Prediction based on the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6). EC50 value was estimated to be 840.24 mg/l for Daphnia magna for 48 hrs duration.

Another prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 5207.131mg/l for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid in 48 hrs.

Read across study for acetylsalicylic acid (50-78-2) from Ecotoxicology and Environmental Safety 59 (2004) 309–315 was performed in Daphnia magna following the European Guideline (Commission of the European Communities,1992). Daphnids were bred in ADaM, a culture medium imitating natural freshwater. Test was performed in 20 degree C with photoperiods of 16 h light/8 h dark. Young daphnids were used in 50 ml of culture volume, each treatment was subdivided in four replicates, each containing 5 daphnia and observed for 24 and 48 hrs. After the experiment the EC 50 value for short term toxicity to aquatic invertebrates for Acetylsalicylic acid (50-78-2) was determined to be 88.1 mg/l. As the Acetylsalicylic acid was considered to toxic to aquatic invertebrates but it is readily biodegradable in nature hence, the Acetylsalicylic acid (50-78-2) was considered to be not classified as per the CLP regulations.

Study was performed in daphnia magna for read across Azepan-2-one (Caprolactam) from J-check, 2010 using OECD guideline 202. The test was performed for 48 hrs and EC 50 value was determined. After 48 hrs, the EC 50 value for Azepan-2-one (Caprolactam) for short term toxicity to aquatic invertebrates was determined to be >1000 mg/l.

From the same references of J-check, 2010, study of another read across was performed in daphnia magna using OECD guideline 202. The test was performed for 48 hrs and EC 50 value was determined. After 48 hrs, the EC 50 value for Acetic acid ethenyl ester was determined to be 9.2 mg/l.Based on the value, the Acetic acid ethenyl ester was considered to be toxic to aquatic invertebrates but as it was readily biodegradable in nature hence can be considered as not classified as per the CLP regulations.

Based on the all the weight of evidences, it was considered that 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) was considered to be non-toxic to aquatic organism and can be considered to be not classified for toxicity to aquatic organism as per the CLP regulations.

Toxicity to aquatic algae:

Toxicity to algae for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) was summaries with predicted data for target and by using functional read across studies as follows:

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6). EC50 value was estimated to be 140.02mg/l for Desmodesmus subspicatus for 72 h duration.

Based on the prediction done using the EPI Suite ECOSAR version 1.10, the short term toxicity on green algae was predicted for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance was estimated to be 1979.289mg/l for green algae in 96 duration.

Another prediction done using the three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database, the short term toxicity on green algae was predicted for 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid. The average EC50 value was given by the third model i.e, Battery model. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid is estimated to be 1236.04 mg/l for Pseudokirchneriella subcapitata during 72 hr exposure duration. Thus, on the basis of EC50 value, it can be concluded that the7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Toxicity to aquatic algae was performed in read across, Acetic acid ethenyl ester (108-05-4) from J-check,2010 according to the OECD Guideline 201 (Alga, Growth Inhibition Test). After the 72 hrs, EC 50 and NOEC value was determined to be 8.9 and 0.20 mg/l on the basis of growth rate and EC 50 and NOEC value for Acetic acid ethenyl ester was determined to be 8.8 and 2.1 mg/l on the basis of AUG. Based on the EC 50 value, Acetic acid ethenyl ester (108-05-4) was considered to be toxic to algae but as it was readily biodegradable in nature it can be considered as not classified as per the CLP regulations.

Based on the all the weight of evidences, it was considered that 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (132-87-6) was considered to be non-toxic to aquatic organism and can be considered to be not classified for toxicity to aquatic organism as per the CLP regulations.