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EC number: 208-523-8 | CAS number: 532-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Amended Safety Assessment of Sodium Polynaphthalene sulfonate and Sodium Naphthalenesulfonate
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 003
- Bibliographic source:
- International Journal of Toxicology, 22(Suppl. 2):37–44, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To evaluate the toxicity of Sodium naphthalene-beta-sulfonate in white rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium naphthalene-2-sulphonate
- EC Number:
- 208-523-8
- EC Name:
- Sodium naphthalene-2-sulphonate
- Cas Number:
- 532-02-5
- Molecular formula:
- C10H8O3S.Na
- IUPAC Name:
- sodium naphthalene-2-sulphonate
- Reference substance name:
- Sodium 2-naphthalenesulfonate
- IUPAC Name:
- Sodium 2-naphthalenesulfonate
- Details on test material:
- - Name of test material (as cited in study report): sodium 2-naphthalenesulfonate
- Molecular formula (if other than submission substance): C10H8O3S.Na
- Molecular weight (if other than submission substance): 230.23 g/mol
- Substance type: Organic
- Physical state: No data available
Purity
- Impurities (identity and concentrations): Not more than 0.5% sulfate (as sodium sulfate); not more than 20 mg/kg of heavy metals; and not more than 2 mg/kg arsenic.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 ml (approximately 64 mg) of SNS was placed into the conjunctival sac of the right eye.
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 1, 24, 48, and 72 h. Additional observations were made on days 5 and 7 to assess the reversibility of any ocular effects.
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Reversibility:
- not specified
- Remarks on result:
- other: Areas of translucent corneal opacity persisted in one treated eye at the day 5 observation. Sloughing of the cornea was noted in one treated eye at day 5, but the other two animals’ eyes returned to normal at day 7
- Irritant / corrosive response data:
- For the conjunctivae, redness, chemosis, and discharge were determined and for the cornea, degree of opacity and area of opacity were determined. Any damage to the iris was noted. Assessments were made at 1, 24, 48, and 72 h. Additional observations were made on days 5 and 7 to assess the reversibility of any ocular effects. Areas of diffuse corneal opacity were noted in all treated eyes at 1 and 24 h, which lessened at 48 and 72 h.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Sodium 2-naphthalenesulfonate was found to be moderate irritant to rabbit eye
- Executive summary:
In eye irritation study three New Zealand white rabbits was observed for Sodium 2-naphthalenesulfonate. One drop of local anesthetic was instilled into both eyes at 3-min intervals over a period of 15-min before treatment. A volume of 0.1 ml (approximately 64 mg) of SNS was placed into the conjunctival sac of the right eye. For the conjunctivae, redness, chemosis, and discharge were determined and for the cornea, degree of opacity and area of opacity were determined. Any damage to the iris was noted. Assessments were made at 1, 24, 48, and 72 h. Additional observations were made on days 5 and 7 to assess the reversibility of any ocular effects. Areas of diffuse corneal opacity were noted in all treatedeyes at 1 and 24 h, which lessened at 48 and 72 h. Areas of translucent corneal opacity persisted in one treated eye at the day 5 observation. Sloughing of the cornea was noted in one treated eye at day 5, but the other two animals’ eyes returned to normal at day 7.The authors concluded that (SNS)Sodium 2-naphthalenesulfonatewas at least a moderate irritant to the rabbit eye. Because one rabbit showed irreversible ocular damage, the test material was viewed as corrosive to the eye
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