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EC number: 209-795-0 | CAS number: 593-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, repeated dose toxicity was predicted for the test compound Methylamine hydrochloride ( IUPAC name: Methanaminium chloride). The study assumed the use of Crj: CD(SD) rats in 13 weeks study. No significant alterations were noted at the mentioned dose level. The predicted No Observed ADverse Effect Level (NOAEL) for Methylamine hydrochloride is considered to be 2670.75 mg/Kg bw/day. Based on this value it can be concluded that the substance is considered to not toxic as per the criteria mentioned in CLP regulation.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from prediction database and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Prediction is done using OECD QSAR toolbox version 3.3
- GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: Methylamine hydrochloride
- IUPAC name: Methanaminium chloride
- Molecular formula: CH5NClH
- Molecular weight: 67.5184 g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data
- Impurities (identity and concentrations): No data - Species:
- rat
- Strain:
- Crj: CD(SD)
- Details on species / strain selection:
- No data
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: unspecified
- Details on route of administration:
- No data
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- No data
- Remarks:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Positive control:
- No data
- Observations and examinations performed and frequency:
- No data
- Sacrifice and pathology:
- No data
- Other examinations:
- No data
- Statistics:
- No data
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Details on results:
- No data
- Dose descriptor:
- NOAEL
- Effect level:
- 2 670.75 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No significnat alterations were observed
- Critical effects observed:
- not specified
- Conclusions:
- The predicted No Observed ADverse Effect Level (NOAEL) for Methylamine hydrochloride is considered to be 2670.75 mg/Kg bw/day.
- Executive summary:
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, repeated dose toxicity was predicted for the test compound Methylamine hydrochloride ( IUPAC name: Methanaminium chloride). The study assumed the use of Crj: CD(SD) rats in 13 weeks study. No significant alterations were noted at the mentioned dose level. The predicted No Observed ADverse Effect Level (NOAEL) for Methylamine hydrochloride is considered to be 2670.75 mg/Kg bw/day.
Based on this value it can be concluded that the substance is considered to not toxic as per the criteria mentioned in CLP regulation.
Reference
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and (("h"
or "i" or "j" or "k" or "l" )
and ("m"
and (
not "n")
)
)
and (("o"
or "p" or "q" or "r" or "s" )
and ("t"
and (
not "u")
)
)
and (("v"
or "w" or "x" or "y" or "z" )
and ("aa"
and (
not "ab")
)
)
and (("ac"
or "ad" or "ae" or "af" or "ag" )
and ("ah"
and (
not "ai")
)
)
)
and "aj" )
and ("ak"
and (
not "al")
)
)
and ("am"
and (
not "an")
)
)
and "ao" )
and "ap" )
and ("aq"
and "ar" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ammonium salt by Organic Functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino,
aliphatic attach [-NH2] AND Nitrogen, hydrogen attach {v+5} by Organic
functional groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Anion AND Cation AND Primary
aliphatic amine AND Primary amine by Organic functional groups, Norbert
Haider (checkmol)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Flavonoids OR AN2 >> Michael-type addition, quinoid
structures >> Quinoneimines OR AN2 >> Michael-type addition, quinoid
structures >> Quinones OR AN2 >> Carbamoylation after isocyanate
formation OR AN2 >> Carbamoylation after isocyanate formation >>
Hydroxamic Acids OR AN2 >> Carbamoylation after isocyanate formation >>
N-Hydroxylamines OR AN2 >> Michael-type addition on alpha,
beta-unsaturated carbonyl compounds OR AN2 >> Michael-type addition on
alpha, beta-unsaturated carbonyl compounds >> Four- and Five-Membered
Lactones OR AN2 >> Nucleophilic addition to alpha, beta-unsaturated
carbonyl compounds OR AN2 >> Nucleophilic addition to alpha,
beta-unsaturated carbonyl compounds >> alpha, beta-Unsaturated Aldehydes
OR AN2 >> Nucleophilic addition to metabolically formed thioketenes OR
AN2 >> Nucleophilic addition to metabolically formed thioketenes >>
Haloalkene Cysteine S-Conjugates OR AN2 >> Schiff base formation OR AN2
>> Schiff base formation >> alpha, beta-Unsaturated Aldehydes OR AN2 >>
Schiff base formation >> Polarized Haloalkene Derivatives OR AN2 >>
Schiff base formation by aldehyde formed after metabolic activation OR
AN2 >> Schiff base formation by aldehyde formed after metabolic
activation >> Geminal Polyhaloalkane Derivatives OR AN2 >> Schiff base
formation by aldehyde formed after metabolic activation >> N-methylol
derivatives OR AN2 >> Shiff base formation after aldehyde release OR AN2
>> Shiff base formation after aldehyde release >> Specific Acetate
Esters OR AN2 >> Shiff base formation for aldehydes OR AN2 >> Shiff base
formation for aldehydes >> Geminal Polyhaloalkane Derivatives OR AN2 >>
Shiff base formation for aldehydes >> Haloalkane Derivatives with Labile
Halogen OR AN2 >> Thioacylation via nucleophilic addition after
cysteine-mediated thioketene formation OR AN2 >> Thioacylation via
nucleophilic addition after cysteine-mediated thioketene formation >>
Haloalkenes with Electron-Withdrawing Groups OR AN2 >> Thioacylation via
nucleophilic addition after cysteine-mediated thioketene formation >>
Polarized Haloalkene Derivatives OR Non-covalent interaction OR
Non-covalent interaction >> DNA intercalation OR Non-covalent
interaction >> DNA intercalation >> Acridone, Thioxanthone, Xanthone and
Phenazine Derivatives OR Non-covalent interaction >> DNA intercalation
>> Aminoacridine DNA Intercalators OR Non-covalent interaction >> DNA
intercalation >> Coumarins OR Non-covalent interaction >> DNA
intercalation >> DNA Intercalators with Carboxamide Side Chain OR
Non-covalent interaction >> DNA intercalation >> Fused-Ring
Nitroaromatics OR Non-covalent interaction >> DNA intercalation >>
Fused-Ring Primary Aromatic Amines OR Non-covalent interaction >> DNA
intercalation >> Quinones OR Non-specific OR Non-specific >>
Incorporation into DNA/RNA, due to structural analogy with nucleoside
bases OR Non-specific >> Incorporation into DNA/RNA, due to
structural analogy with nucleoside bases >> Specific Imine and
Thione Derivatives OR Radical OR Radical >> Generation of reactive
oxygen species OR Radical >> Generation of reactive oxygen species >>
Thiols OR Radical >> Generation of ROS by glutathione depletion
(indirect) OR Radical >> Generation of ROS by glutathione depletion
(indirect) >> Haloalkanes Containing Heteroatom OR Radical >> Radical
mechanism by ROS formation OR Radical >> Radical mechanism by ROS
formation (indirect) or direct radical attack on DNA OR Radical >>
Radical mechanism by ROS formation (indirect) or direct radical attack
on DNA >> Organic Peroxy Compounds OR Radical >> Radical mechanism by
ROS formation >> Acridone, Thioxanthone, Xanthone and Phenazine
Derivatives OR Radical >> Radical mechanism by ROS formation >>
Polynitroarenes OR Radical >> Radical mechanism via ROS formation
(indirect) OR Radical >> Radical mechanism via ROS formation (indirect)
>> C-Nitroso Compounds OR Radical >> Radical mechanism via ROS formation
(indirect) >> Conjugated Nitro Compounds OR Radical >> Radical mechanism
via ROS formation (indirect) >> Coumarins OR Radical >> Radical
mechanism via ROS formation (indirect) >> Flavonoids OR Radical >>
Radical mechanism via ROS formation (indirect) >> Fused-Ring
Nitroaromatics OR Radical >> Radical mechanism via ROS formation
(indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >> Radical
mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane
Derivatives OR Radical >> Radical mechanism via ROS formation (indirect)
>> Haloalcohols OR Radical >> Radical mechanism via ROS formation
(indirect) >> Hydrazine Derivatives OR Radical >> Radical mechanism via
ROS formation (indirect) >> N-Hydroxylamines OR Radical >> Radical
mechanism via ROS formation (indirect) >> Nitro Azoarenes OR Radical >>
Radical mechanism via ROS formation (indirect) >> Nitroaniline
Derivatives OR Radical >> Radical mechanism via ROS formation (indirect)
>> Nitroarenes with Other Active Groups OR Radical >> Radical mechanism
via ROS formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and
Nitrobenzoic Acids OR Radical >> Radical mechanism via ROS formation
(indirect) >> p-Aminobiphenyl Analogs OR Radical >> Radical mechanism
via ROS formation (indirect) >> p-Substituted Mononitrobenzenes OR
Radical >> Radical mechanism via ROS formation (indirect) >> Quinones OR
Radical >> Radical mechanism via ROS formation (indirect) >> Single-Ring
Substituted Primary Aromatic Amines OR Radical >> Radical mechanism via
ROS formation (indirect) >> Specific Imine and Thione Derivatives OR
Radical >> ROS formation after GSH depletion (indirect) OR Radical >>
ROS formation after GSH depletion (indirect) >> Quinoneimines OR SN1 OR
SN1 >> Alkylation after metabolically formed carbenium ion species OR
SN1 >> Alkylation after metabolically formed carbenium ion species >>
Polycyclic Aromatic Hydrocarbon Derivatives OR SN1 >> Carbenium ion
formation OR SN1 >> Carbenium ion formation >> Alpha-Haloethers OR SN1
>> DNA bases alkylation by carbenium ion formed OR SN1 >> DNA bases
alkylation by carbenium ion formed >> Diazoalkanes OR SN1 >>
Nucleophilic attack after carbenium ion formation OR SN1 >> Nucleophilic
attack after carbenium ion formation >> N-Nitroso Compounds OR SN1 >>
Nucleophilic attack after carbenium ion formation >> Pyrrolizidine
Derivatives OR SN1 >> Nucleophilic attack after carbenium ion formation
>> Specific Acetate Esters OR SN1 >> Nucleophilic attack after diazonium
or carbenium ion formation OR SN1 >> Nucleophilic attack after diazonium
or carbenium ion formation >> Nitroarenes with Other Active Groups OR
SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR
SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >>
Fused-Ring Primary Aromatic Amines OR SN1 >> Nucleophilic attack after
metabolic nitrenium ion formation >> N-Hydroxylamines OR SN1 >>
Nucleophilic attack after metabolic nitrenium ion formation >>
p-Aminobiphenyl Analogs OR SN1 >> Nucleophilic attack after metabolic
nitrenium ion formation >> Single-Ring Substituted Primary Aromatic
Amines OR SN1 >> Nucleophilic attack after nitrenium and/or carbenium
ion formation OR SN1 >> Nucleophilic attack after nitrenium and/or
carbenium ion formation >> N-Nitroso Compounds OR SN1 >> Nucleophilic
attack after reduction and nitrenium ion formation OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation >>
Conjugated Nitro Compounds OR SN1 >> Nucleophilic attack after reduction
and nitrenium ion formation >> Fused-Ring Nitroaromatics OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation >> Nitro
Azoarenes OR SN1 >> Nucleophilic attack after reduction and nitrenium
ion formation >> Nitroaniline Derivatives OR SN1 >> Nucleophilic attack
after reduction and nitrenium ion formation >> Nitroarenes with Other
Active Groups OR SN1 >> Nucleophilic attack after reduction and
nitrenium ion formation >> Nitrobiphenyls and Bridged Nitrobiphenyls OR
SN1 >> Nucleophilic attack after reduction and nitrenium ion formation
>> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation >>
Polynitroarenes OR SN1 >> Nucleophilic attack after reduction and
nitrenium ion formation >> p-Substituted Mononitrobenzenes OR SN1 >>
Nucleophilic substitution after glutathione-induced nitrenium ion
formation OR SN1 >> Nucleophilic substitution after glutathione-induced
nitrenium ion formation >> C-Nitroso Compounds OR SN1 >> Nucleophilic
substitution on diazonium ions OR SN1 >> Nucleophilic substitution on
diazonium ions >> Specific Imine and Thione Derivatives OR SN2 OR SN2 >>
Acylation OR SN2 >> Acylation >> Hydroxamic Acids OR SN2 >> Acylation >>
Specific Acetate Esters OR SN2 >> Acylation involving a leaving group
OR SN2 >> Acylation involving a leaving group >> Geminal
Polyhaloalkane Derivatives OR SN2 >> Acylation involving a leaving group
>> Haloalkane Derivatives with Labile Halogen OR SN2 >> Acylation
involving a leaving group after metabolic activation OR SN2 >> Acylation
involving a leaving group after metabolic activation >> Geminal
Polyhaloalkane Derivatives OR SN2 >> Alkylation by epoxide metabolically
formed after E2 reaction OR SN2 >> Alkylation by epoxide metabolically
formed after E2 reaction >> Haloalcohols OR SN2 >> Alkylation, direct
acting epoxides and related OR SN2 >> Alkylation, direct acting epoxides
and related >> Epoxides and Aziridines OR SN2 >> Alkylation, direct
acting epoxides and related after cyclization OR SN2 >> Alkylation,
direct acting epoxides and related after cyclization >> Nitrogen
Mustards OR SN2 >> Alkylation, direct acting epoxides and related after
P450-mediated metabolic activation OR SN2 >> Alkylation, direct acting
epoxides and related after P450-mediated metabolic activation >>
Haloalkenes with Electron-Withdrawing Groups OR SN2 >> Alkylation,
direct acting epoxides and related after P450-mediated metabolic
activation >> Polycyclic Aromatic Hydrocarbon Derivatives OR SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom OR SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom >> Haloalkane
Derivatives with Labile Halogen OR SN2 >> Alkylation, nucleophilic
substitution at sp3-carbon atom >> Sulfonates and Sulfates OR SN2 >>
Alkylation, ring opening SN2 reaction OR SN2 >> Alkylation, ring opening
SN2 reaction >> Four- and Five-Membered Lactones OR SN2 >> Direct acting
epoxides formed after metabolic activation OR SN2 >> Direct acting
epoxides formed after metabolic activation >> Coumarins OR SN2 >> Direct
acting epoxides formed after metabolic activation >> Quinoline
Derivatives OR SN2 >> Direct acylation involving a leaving group OR SN2
>> Direct acylation involving a leaving group >> Acyl Halides OR SN2 >>
DNA alkylation OR SN2 >> DNA alkylation >> Alkylphosphates,
Alkylthiophosphates and Alkylphosphonates OR SN2 >> DNA alkylation >>
Vicinal Dihaloalkanes OR SN2 >> Internal SN2 reaction with aziridinium
and/or cyclic sulfonium ion formation (enzymatic) OR SN2 >> Internal SN2
reaction with aziridinium and/or cyclic sulfonium ion formation
(enzymatic) >> Vicinal Dihaloalkanes OR SN2 >> Nucleophilic substitution
at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at sp3 Carbon
atom >> Haloalkanes Containing Heteroatom OR SN2 >> Nucleophilic
substitution at sp3 Carbon atom >> Specific Acetate Esters OR SN2 >>
Nucleophilic substitution at sp3 carbon atom after thiol (glutathione)
conjugation OR SN2 >> Nucleophilic substitution at sp3 carbon atom after
thiol (glutathione) conjugation >> Geminal Polyhaloalkane Derivatives OR
SN2 >> SN2 at an activated carbon atom OR SN2 >> SN2 at an activated
carbon atom >> Quinoline Derivatives OR SN2 >> SN2 at Nitrogen Atom OR
SN2 >> SN2 at Nitrogen Atom >> N-acetoxyamines OR SN2 >> SN2 at sp3 and
activated sp2 carbon atom OR SN2 >> SN2 at sp3 and activated sp2 carbon
atom >> Polarized Haloalkene Derivatives OR SN2 >> SN2 at sp3-carbon
atom OR SN2 >> SN2 at sp3-carbon atom >> Alpha-Haloethers OR SN2 >> SN2
attack on activated carbon Csp3 or Csp2 OR SN2 >> SN2 attack on
activated carbon Csp3 or Csp2 >> Nitroarenes with Other Active Groups OR
SN2 >> SN2 reaction at nitrogen-atom bound to a good leaving group OR
SN2 >> SN2 reaction at nitrogen-atom bound to a good leaving group >>
N-Acetoxyamines by DNA binding by OASIS v.1.3
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ammonium salt by Organic Functional groups
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino,
aliphatic attach [-NH2] AND Nitrogen, hydrogen attach {v+5} by Organic
functional groups (US EPA)
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Anion AND Cation AND Primary
aliphatic amine AND Primary amine by Organic functional groups, Norbert
Haider (checkmol)
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Addition of an Acyl Halide OR Acylation >> Direct Addition of an Acyl
Halide >> Acyl halide OR Acylation >> P450 Mediated Activation to Acyl
Halides OR Acylation >> P450 Mediated Activation to Acyl Halides >>
1,1-Dihaloalkanes OR Acylation >> P450 Mediated Activation to
Isocyanates or Isothiocyanates OR Acylation >> P450 Mediated Activation
to Isocyanates or Isothiocyanates >> Benzylamines-Acylation OR Acylation
>> P450 Mediated Activation to Isocyanates or Isothiocyanates >>
Formamides OR Michael addition OR Michael addition >> P450 Mediated
Activation of Heterocyclic Ring Systems OR Michael addition >> P450
Mediated Activation of Heterocyclic Ring Systems >> Furans OR Michael
addition >> P450 Mediated Activation of Heterocyclic Ring Systems >>
Thiophenes-Michael addition OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals OR Michael addition >>
P450 Mediated Activation to Quinones and Quinone-type Chemicals >>
5-alkoxyindoles OR Michael addition >> P450 Mediated Activation to
Quinones and Quinone-type Chemicals >> Alkyl phenols OR Michael addition
>> P450 Mediated Activation to Quinones and Quinone-type Chemicals >>
Arenes OR Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Hydroquinones OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals >>
Methylenedioxyphenyl OR Michael addition >> P450 Mediated Activation to
Quinones and Quinone-type Chemicals >> Polycyclic (PAHs) and
heterocyclic (HACs) aromatic hydrocarbons-Michael addition OR Michael
addition >> Polarised Alkenes-Michael addition OR Michael addition >>
Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated amides OR
Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated esters OR Michael addition >> Polarised Alkenes-Michael
addition >> Alpha, beta- unsaturated ketones OR Michael addition >>
Quinones and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Quinone-imines OR Michael addition >> Quinones
and Quinone-type Chemicals >> Quinones OR Schiff base formers OR Schiff
base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff base
formers >> Chemicals Activated by P450 to Glyoxal >> Ethanolamines
(including morpholine) OR Schiff base formers >> Chemicals Activated by
P450 to Glyoxal >> Ethylenediamines (including piperazine) OR Schiff
base formers >> Chemicals Activated by P450 to Mono-aldehydes OR Schiff
base formers >> Chemicals Activated by P450 to Mono-aldehydes >>
Benzylamines-Schiff base OR Schiff base formers >> Chemicals Activated
by P450 to Mono-aldehydes >> N-methylol derivates OR Schiff base formers
>> Chemicals Activated by P450 to Mono-aldehydes >> Thiazoles OR Schiff
base formers >> Direct Acting Schiff Base Formers OR Schiff base formers
>> Direct Acting Schiff Base Formers >> Mono aldehydes OR SN1 OR SN1 >>
Carbenium Ion Formation OR SN1 >> Carbenium Ion Formation >> Allyl
benzenes OR SN1 >> Carbenium Ion Formation >> Alpha halo ethers
(including alpha halo thioethers) OR SN1 >> Carbenium Ion Formation >>
Diazoalkanes OR SN1 >> Carbenium Ion Formation >> Hydrazine OR SN1 >>
Carbenium Ion Formation >> N-Nitroso (alkylation) OR SN1 >> Carbenium
Ion Formation >> Polycyclic (PAHs) and heterocyclic (HACs) aromatic
hydrocarbons-SN1 OR SN1 >> Carbenium Ion Formation >> Pyrrolizidine
alkaloids OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion
Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation
OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1 >> Nitrenium
Ion formation >> Aromatic nitro OR SN1 >> Nitrenium Ion formation >>
Aromatic phenylureas OR SN1 >> Nitrenium Ion formation >> Primary
(unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >>
Primary aromatic amine OR SN1 >> Nitrenium Ion formation >> Secondary
(unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >>
Secondary aromatic amine OR SN1 >> Nitrenium Ion formation >> Tertiary
(unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >>
Tertiary aromatic amine OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic azo OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic nitro OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic phenylureas OR SN2 OR SN2 >> Direct Acting Epoxides and
related OR SN2 >> Direct Acting Epoxides and related >> Aziridines OR
SN2 >> Direct Acting Epoxides and related >> Epoxides OR SN2 >>
Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation >>
1,2-Dihaloalkanes OR SN2 >> Episulfonium Ion Formation >> Mustards OR
SN2 >> Epoxidation of Aliphatic Alkenes OR SN2 >> Epoxidation of
Aliphatic Alkenes >> Halogenated polarised alkenes OR SN2 >>
Nitrosation-SN2 OR SN2 >> Nitrosation-SN2 >> Nitroso-SN2 OR SN2 >> P450
Mediated Epoxidation OR SN2 >> P450 Mediated Epoxidation >>
Thiophenes-SN2 OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at an
sp3 Carbon atom >> Aliphatic halides OR SN2 >> SN2 at an sp3 Carbon atom
>> Alkyl carbamates OR SN2 >> SN2 at an sp3 Carbon atom >> Phosphonates
OR SN2 >> SN2 at an sp3 Carbon atom >> Phosphonic esters OR SN2 >> SN2
at an sp3 Carbon atom >> Sulfonates by DNA binding by OECD
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ammonium salt by Organic Functional groups
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino,
aliphatic attach [-NH2] AND Nitrogen, hydrogen attach {v+5} by Organic
functional groups (US EPA)
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Anion AND Cation AND Primary
aliphatic amine AND Primary amine by Organic functional groups, Norbert
Haider (checkmol)
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Non binder, non cyclic structure
by Estrogen Receptor Binding
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, without OH or NH2 group OR Strong
binder, NH2 group OR Strong binder, OH group OR Very strong binder, OH
group OR Weak binder, NH2 group OR Weak binder, OH group by Estrogen
Receptor Binding
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ammonium salt by Organic Functional groups
Domain
logical expression index: "x"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "y"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino,
aliphatic attach [-NH2] AND Nitrogen, hydrogen attach {v+5} by Organic
functional groups (US EPA)
Domain
logical expression index: "z"
Referential
boundary: The
target chemical should be classified as Anion AND Cation AND Primary
aliphatic amine AND Primary amine by Organic functional groups, Norbert
Haider (checkmol)
Domain
logical expression index: "aa"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS v1.3
Domain
logical expression index: "ab"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Acyl
transfer via nucleophilic addition reaction OR Acylation >> Acyl
transfer via nucleophilic addition reaction >> Carbodiimides OR
Acylation >> Direct acylation involving a leaving group OR Acylation >>
Direct acylation involving a leaving group >> (Thio)Acyl and
(thio)carbamoyl halides and cyanides OR Acylation >> Direct acylation
involving a leaving group >> Anhydrides (sulphur analogues of
anhydrides) OR Acylation >> Direct acylation involving a leaving group
>> Azlactones and unsaturated lactone derivatives OR Acylation >>
Direct acylation involving a leaving group >> Carbamates OR Acylation
>> Direct acylation involving a leaving group >> N-Acylsulfonamides OR
Acylation >> Direct acylation involving a leaving group >>
Thiosulfinates OR Acylation >> Direct acylation involving a leaving
group >> Thiosulfonates OR Acylation >> Ester aminolysis OR Acylation >>
Ester aminolysis >> Amides OR Acylation >> Ester aminolysis >>
Dithiocarbamates OR Acylation >> Ester aminolysis or thiolysis OR
Acylation >> Ester aminolysis or thiolysis >> Activated aryl esters OR
Acylation >> Ring opening acylation OR Acylation >> Ring opening
acylation >> beta-Lactams OR Ionic interaction OR Ionic interaction >>
Electrostatic interaction of tetraalkylamonium ion with protein
carboxylates OR Ionic interaction >> Electrostatic interaction of
tetraalkylamonium ion with protein carboxylates >> Tetraalkylammonium
ions OR Michael Addition OR Michael Addition >> alpha,beta-Unsaturated
carbonyl compounds OR Michael Addition >> alpha,beta-Unsaturated
carbonyl compounds >> alpha,beta-Aldehydes OR Michael Addition >>
Michael addition on conjugated systems with electron withdrawing group
OR Michael Addition >> Michael addition on conjugated systems with
electron withdrawing group >> alpha,beta-Carbonyl compounds with
polarized double bonds OR Michael Addition >> Michael addition on
conjugated systems with electron withdrawing group >> Conjugated systems
with electron withdrawing groups OR Michael Addition >> Michael
addition on conjugated systems with electron withdrawing group >>
Cyanoalkenes OR Michael Addition >> Michael addition on conjugated
systems with electron withdrawing group >> Nitroalkenes OR Michael
Addition >> Polarised Alkenes OR Michael Addition >> Polarised Alkenes
>> Polarised Alkene - alkenyl pyridines, pyrazines, pyrimidines or
triazines OR Michael Addition >> Polarised Alkenes >> Polarised Alkenes
- sulfones OR Michael Addition >> Quinoide type compounds OR Michael
Addition >> Quinoide type compounds >> Quinone methide(s)/imines;
Quinoide oxime structure; Nitroquinones, Naphthoquinone(s)/imines OR
Michael Addition >> Quinone type chemicals OR Michael Addition >>
Quinone type chemicals >> Pyranones, Pyridones (and related nitrogen
chemicals) OR Nucleophilic addition OR Nucleophilic addition >>
Addition to carbon-hetero double bonds OR Nucleophilic addition >>
Addition to carbon-hetero double bonds >> Azomethyme type compounds OR
Nucleophilic addition >> Addition to carbon-hetero double bonds >>
Ketones OR Nucleophilic addition >> Nucleophilic addition reaction at
polarized N-functional double bond OR Nucleophilic addition >>
Nucleophilic addition reaction at polarized N-functional double bond >>
C-Nitroso compounds OR Radical reactions OR Radical reactions >> Free
radical formation OR Radical reactions >> Free radical formation >>
Hydroperoxides OR Radical reactions >> Free radical formation >> Organic
peroxy compounds OR Schiff base formation OR Schiff base formation >>
Direct acting Schiff base formers OR Schiff base formation >> Direct
acting Schiff base formers >> 1,2-Dicarbonyls and 1,3-Dicarbonyls OR
Schiff base formation >> Direct acting Schiff base formers >>
Di-substituted alpha,beta-unsaturated aldehydes OR Schiff base
formation >> Pyrazolones and Pyrazolidinones derivatives OR Schiff base
formation >> Pyrazolones and Pyrazolidinones derivatives >> Pyrazolones
and Pyrazolidinones OR Schiff base formation >> Schiff base formation
with carbonyl compounds OR Schiff base formation >> Schiff base
formation with carbonyl compounds >> Aldehydes OR SN1 OR SN1 >>
Carbenium ion formation (enzymatic) OR SN1 >> Carbenium ion formation
(enzymatic) >> Carbenium ion OR SN2 OR SN2 >> Interchange reaction with
sulphur containing compounds OR SN2 >> Interchange reaction with sulphur
containing compounds >> Thiols and disulfide compounds OR SN2 >>
Nucleophilic substitution at a Nitrogen atom OR SN2 >> Nucleophilic
substitution at a Nitrogen atom >> N-Nitroso compounds OR SN2 >>
Nucleophilic substitution at sp3 carbon atom OR SN2 >> Nucleophilic
substitution at sp3 carbon atom >> (Thio)Phosphates OR SN2 >>
Nucleophilic substitution at sp3 carbon atom >> Alkyl halides OR SN2 >>
Nucleophilic substitution at sp3 carbon atom >> alpha-Activated
haloalkanes OR SN2 >> Nucleophilic substitution at sp3 carbon atom >>
N-Nitroso compounds OR SN2 >> Nucleophilic substitution at sp3 carbon
atom >> Phosphonates OR SN2 >> Nucleophilic substitution at sp3 carbon
atom >> Sulfonates OR SN2 >> Nucleophilic substitution at the central
carbon atom of N-nitroso compounds OR SN2 >> Nucleophilic substitution
at the central carbon atom of N-nitroso compounds >> N-Nitroso_compounds
OR SN2 >> Nucleophilic substitution on a sulphur atom OR SN2 >>
Nucleophilic substitution on a sulphur atom >> Organic thiosulfates OR
SN2 >> Nucleophilic substitution on benzilyc carbon atom OR SN2 >>
Nucleophilic substitution on benzilyc carbon atom >> alpha-Activated
benzyls OR SN2 >> Ring opening SN2 reaction OR SN2 >> Ring opening SN2
reaction >> Epoxides, Aziridines and Sulfuranes OR SN2 >> SN2 Reaction
at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >>
Activated alkyl esters and thioesters OR SN2 >> SN2 reaction at a
sulfur atom OR SN2 >> SN2 reaction at a sulfur atom >> Thiocyanates OR
SN2 Ionic OR SN2 Ionic >> Nucleophilic substitution at protein disulfide
bonds involving S-nucleophiles OR SN2 Ionic >> Nucleophilic substitution
at protein disulfide bonds involving S-nucleophiles >> Thiourea
compounds OR SNAr OR SNAr >> Nucleophilic aromatic substitution on
activated aryl and heteroaryl compounds OR SNAr >> Nucleophilic aromatic
substitution on activated aryl and heteroaryl compounds >> Activated
aryl and heteroaryl compounds OR SNVinyl OR SNVinyl >> SNVinyl at a
vinylic (sp2) carbon atom OR SNVinyl >> SNVinyl at a vinylic (sp2)
carbon atom >> Vinyl type compounds with electron withdrawing groups by
Protein binding by OASIS v1.3
Domain
logical expression index: "ac"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "ad"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary AND
Ammonium salt by Organic Functional groups
Domain
logical expression index: "ae"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, primary by
Organic Functional groups (nested)
Domain
logical expression index: "af"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino,
aliphatic attach [-NH2] AND Nitrogen, hydrogen attach {v+5} by Organic
functional groups (US EPA)
Domain
logical expression index: "ag"
Referential
boundary: The
target chemical should be classified as Anion AND Cation AND Primary
aliphatic amine AND Primary amine by Organic functional groups, Norbert
Haider (checkmol)
Domain
logical expression index: "ah"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "ai"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation
Involving a Leaving group >> Acyl halides (including benzyl and
carbamoyl deriv.) OR Acylation >> Direct Acylation Involving a Leaving
group >> Azlactone OR Acylation >> Isocyanates and Related Chemicals OR
Acylation >> Isocyanates and Related Chemicals >> Carbodiimides OR
Acylation >> Isocyanates and Related Chemicals >> Ketenes OR Acylation
>> Isocyanates and Related Chemicals >> Thiocyanates-Acylation OR
Acylation >> Ring Opening Acylation OR Acylation >> Ring Opening
Acylation >> alpha-Lactams OR Michael addition OR Michael addition >>
Acid imides OR Michael addition >> Acid imides >> Acid imides-MA OR
Michael addition >> Polarised Alkenes OR Michael addition >> Polarised
Alkenes >> Polarised alkene - amides OR Michael addition >> Polarised
Alkenes >> Polarised alkene - esters OR Michael addition >> Polarised
Alkenes >> Polarised alkene - ketones OR Michael addition >> Polarised
Alkenes >> Polarised alkene - nitro OR Michael addition >> Polarised
Alkenes >> Polarised alkene - pyridines OR Michael addition >> Quinones
and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Pyranones (and related nitrogen chemicals) OR
Michael addition >> Quinones and Quinone-type Chemicals >>
Quinone-diimine OR Michael addition >> Quinones and Quinone-type
Chemicals >> Quinone-imine OR Schiff Base Formers OR Schiff Base Formers
>> Direct Acting Schiff Base Formers OR Schiff Base Formers >> Direct
Acting Schiff Base Formers >> 1-2-Dicarbonyls OR Schiff Base Formers >>
Direct Acting Schiff Base Formers >> Di-substituted alpha,
beta-unsaturated aldehydes OR Schiff Base Formers >> Direct Acting
Schiff Base Formers >> Mono-carbonyls OR SN2 OR SN2 >> Episulfonium Ion
Formation OR SN2 >> Episulfonium Ion Formation >> 1,2-Dihaloalkane OR
SN2 >> Episulfonium Ion Formation >> Mustards OR SN2 >> Epoxides and
Related Chemicals OR SN2 >> Epoxides and Related Chemicals >> Aziridines
OR SN2 >> Epoxides and Related Chemicals >> Epoxides OR SN2 >> SN2
reaction at a nitrogen atom OR SN2 >> SN2 reaction at a nitrogen atom >>
Nitrosoureas (nitrogen) OR SN2 >> SN2 reaction at a sp2 carbon atom OR
SN2 >> SN2 reaction at a sp2 carbon atom >> Polarised alkenes with a
halogen leaving group OR SN2 >> SN2 reaction at a sulphur atom OR SN2 >>
SN2 reaction at a sulphur atom >> Disulfides OR SN2 >> SN2 reaction at a
sulphur atom >> Sulfoxides of disulfides OR SN2 >> SN2 reaction at a
sulphur atom >> Thiocyanates-SN2 OR SN2 >> SN2 reaction at a sulphur
atom >> Thiols OR SN2 >> SN2 reaction at sp3 carbon atom OR SN2 >> SN2
reaction at sp3 carbon atom >> Alkyl diazo OR SN2 >> SN2 reaction at sp3
carbon atom >> Alkyl halides OR SN2 >> SN2 reaction at sp3 carbon atom
>> Allyl acetates and related chemicals OR SN2 >> SN2 reaction at sp3
carbon atom >> alpha-Halobenzyls (and related cyano, sulfate and
sulphonate subs. chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >>
beta-Halo ethers OR SN2 >> SN2 reaction at sp3 carbon atom >>
Nitrosoureas (carbon) OR SN2 >> SN2 reaction at sp3 carbon atom >>
Phosphates OR SN2 >> SN2 reaction at sp3 carbon atom >> Phosphonates OR
SN2 >> SN2 reaction at sp3 carbon atom >> Sulfonates OR SN2 >> SN2
reaction at sp3 carbon atom >> Thiophosphates OR SNAr OR SNAr >>
Nucleophilic aromatic substitution OR SNAr >> Nucleophilic aromatic
substitution >> Activated halo-benzenes OR SNAr >> Nucleophilic aromatic
substitution >> Activated halo-pyridines OR SNAr >> Nucleophilic
aromatic substitution >> Halo-pyrimidines by Protein binding by OECD
Domain
logical expression index: "aj"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "ak"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "al"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Metalloids by
Groups of elements
Domain
logical expression index: "am"
Referential
boundary: The
target chemical should be classified as No alert found by
Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain
logical expression index: "an"
Referential
boundary: The
target chemical should be classified as Phtalate (or buthyl) diesters
and monoesters (Nongenotox) OR Structural alert for nongenotoxic
carcinogenicity OR Substituted n-alkylcarboxylic acids (Nongenotox) by
Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain
logical expression index: "ao"
Referential
boundary: The
target chemical should be classified as Reactive unspecified by Acute
aquatic toxicity MOA by OASIS ONLY
Domain
logical expression index: "ap"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "aq"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -4
Domain
logical expression index: "ar"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -2.08
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 2 670.75 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- Data is from prediction database
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated dose toxicity: Oral
Prediction data for the target chemical and various data available to determine the toxic nature of Methylamine hydrochloride ( IUPAC name: Methanaminium chloride) was reviewed. The summary is as mentioned below:
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, repeated dose toxicity was predicted for the test compound Methylamine hydrochloride ( IUPAC name: Methanaminium chloride). The study assumed the use of Crj: CD(SD) rats in 13 weeks study. No significant alterations were noted at the mentioned dose level. The predicted No Observed ADverse Effect Level (NOAEL) for Methylamine hydrochloride is considered to be 2670.75 mg/Kg bw/day. Based on this value it can be concluded that the substance is considered to not toxic.
Combined repeated dose repro-developmental toxicity study was performed (NTRL, 2006) to determine the toxic nature of Methylamine hydrochloride ( IUPAC name: Methanaminium chloride) upon repeated administration by oral route. Groups of 12 rats of each sex per dose level were dosed with methylamine hydrochloride in water once daily by gavage at dose levels of 0, 250, 500, or 1000 mg/kg/day. Following a 71-day premating period, P1 males and females were co-housed for up to 2 weeks within their respective treatment groups to produce F1 litters. Dams were allowed to deliver and rear their offspring until postpartum day 4. All P1 rats were given a gross pathological examination at terminal sacrifice. Uterine implantation sites and ovarian corpora lutea were counted in PI females. A histological examination of all tissues saved was conducted for all animals in the control and 1000 mg /kg /day group. Tissue examination in the other groups was limited to relevant gross lesions and tissues demonstrating treatment-related histological effects at 1000 mg/kg/day. Significant changes in body weight and food consumtion were observed at 1000 mg/kg/day. Significantly reduced corpora lutea counts and subsequently lower implantation site counts and litter sizes at 1000 mg/kg/day was observed. No significant changes were observed at 0, 250, or 500 mg/kg/day. The No Observed Adverse Effect Level (NOAEL) is considered to be 500 mg/kg/day for Methylamine hydrochloride in male and female rats by oral gavage.
Sarker and Sastry ( Indian Journal of Animal Sciences, 1990) performed subchronic repeated dose toxicity study to determine the toxic nature of Methylamine hydrochloride. The test chemical was dosed orally at 1000 mg/Kg/day for ≤90 days in rats. The animals were observed for changes in growth rate and clinical signs. Organ weight and gross pathological lesions were also observed. The clinical chemistry serum levelsof GOT, GPT, lactate dehydrogenase, and alkaline phosphatase were observed in the treated animals. The treated animals did not show any clinical signs of toxicity and Serum levels of GOT, GPT, lactate dehydrogenase, and alkaline phosphatase were not altered in the treated animals. The animals did not show any alterations in organ weight and no gross organ lesions were noted. On the basis of results observed, No Observed Adverse Effect level (NOAEL) for methylamine hydrochloride is considered to be 1000 mg/Kg/day.
Based on the available weight of evidence data for the target chemical, Methylamine hydrochloride (IUPAC name: Methanaminium chloride) does not exhibit toxic nature upon repeated application by oral route. Thus, the chemical is not likely to be toxic as per the criteria mentioned in CLP regulation.
Justification for classification or non-classification
Based on the available data for the target chemical, Methylamine hydrochloride (IUPAC name: Methanaminium chloride) does not exhibit toxic nature upon repeated application by oral route. Thus, the chemical is not likely to be toxic as per the criteria mentioned in CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.