Registration Dossier
Registration Dossier
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EC number: 205-047-2 | CAS number: 132-16-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- skin irritation tests on rabbits
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- The toxicity of copper is known to be greater than iron so it is considered valid to read-across to the copper complex on the assumption that if the copper complex is not toxic, then the iron complex will not be toxic. Both forms have similar (low) solubility in water and will have equivalent bioavailability.
Further animal testing is not justified.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other:
- Version / remarks:
- unknown; skin irritation tests on rabbits
- Principles of method if other than guideline:
- Skin irritation tests in rabbits with 0.5 g, or with 0.5 ml of a 46%
dispersion produced slight, or slight to moderate erythema and oedema. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- EC Number:
- 205-685-1
- EC Name:
- 29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32 copper
- Cas Number:
- 147-14-8
- Molecular formula:
- C32H16CuN8
- IUPAC Name:
- [29H,31H-phthalocyaninato(2-)-kappa~2~N~29~,N~31~]copper
- Test material form:
- solid: crystalline
Constituent 1
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- physiological saline
- Controls:
- not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Skin irritation tests in rabbits with 0.5 g, or with 0.5 ml of a 46% dispersion of CuPC produced slight, or slight to moderate erythema and oedema. With 100 mg undiluted dye, or with 0.1 ml 25% or 50% in physiological saline, solution no irritation occurred.
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