Registration Dossier
Registration Dossier
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EC number: 203-299-8 | CAS number: 105-45-3
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature; result presented without detailed documentation.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs. Methyl acetoacetate.
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Cosmet Toxicol 16: 815
- Reference Type:
- secondary source
- Title:
- Report to RIFM, 10 May 1976
- Author:
- Kligman AM
- Year:
- 1 976
- Bibliographic source:
- Cited in Opdyke DLJ (1978). Fragrance raw materials monographs. Methyl acetoacetate. Food Cosmet Toxicol 16: 815
Materials and methods
- Type of study / information:
- in vivo
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Closed Patch Test
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl acetoacetate
- EC Number:
- 203-299-8
- EC Name:
- Methyl acetoacetate
- Cas Number:
- 105-45-3
- Molecular formula:
- C5H8O3
- IUPAC Name:
- methyl 3-oxobutanoate
- Details on test material:
- - Name of test material (as cited in study report): methyl acetoacetate;
- Analytical purity: no data
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Methyl acetoacetate was applied full strength to intact or abraded rabbit skin for 24 hr under occlusive conditions (Moreno 1976).
- Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE: skin
EXPOSURE LEVELS: applied concentration: 8 %
EXPOSURE PERIOD: 48 hours
POSTEXPOSURE PERIOD: no data
Results and discussion
- Results:
- In a 48-hour closed patch test with human subjects, the test substance did not produce any irritation when tested at 8% in petrolatum (Kligman 1976).
Any other information on results incl. tables
No further information available.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
