Registration Dossier
Registration Dossier
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EC number: 232-318-2 | CAS number: 8003-22-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 47000.
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The Lethal Concentration 50% (LC50) values of 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) based on the effect of mortality in fish in a 96 hrs study was found to be >0.18mg/L and No mortality observed at 0.18mg/L.
The other weight of evidence studies also indicate the LC50 values to be in the range more than 0.11-0.12 mg/L. Thus, considering only the LC50 values, the studies indicate Aquatic toxicity since though the LC50 values are in the classifying, as the range is not specified. Considering the weight of evidence results 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) is not classified.
Key value for chemical safety assessment
Additional information
No. of studies were reviewed for Short-term toxicity to fish from reliable sources having Klimish rating 2.
The summary of the results are presented below:
Sr. No. |
Endpoint name |
Duration |
Value |
Units |
Species |
Source |
1. |
LC50 |
96 hr |
>0.18 |
mg/L |
Pimephales Fathead minnow |
Data from publication for CAS: 8003-22-3 |
2. |
LC50 |
96 hr |
>0.12 |
mg/L |
Lepomis macrochirus |
Data from publication for CAS: 8003-22-3 |
3. |
LC50 |
96 hr |
>0.11 |
mg/L |
Channel catfish |
Data from publication for CAS: 8003-22-3 |
No mortality observed at any values indicated in above table alsoas the range is not specified.The substance 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline (D & C Yellow No. 11) will not exhibit aquatic toxicity to fish.
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