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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hexachloroacetone
- EC Number:
- 204-129-5
- EC Name:
- Hexachloroacetone
- Cas Number:
- 116-16-5
- Molecular formula:
- C3Cl6O
- IUPAC Name:
- hexachloropropan-2-one
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Hexachloraceton
- Physical state: colourless liquid
- Analytical purity: 99.52%
- Lot/batch No.: 1HC109004
- Expiration date of the lot/batch: 2002-12-31
- Stability under storage conditions: at +25°C: < 1 year
- Storage condition of test material: at room temperature, dark, tightly closed
- Other: density: 1.7431 g/cm³; ph value: 3.2
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source/Breeder: LPT Laboratory of Pharmacology and Toxicology KG; branch Löhndorf; D-24601Löhndorf/Post Wankendorf
- Age at study initiation: approx. 10 months
- Weight at study initiation: 2.6-2.9 kg
- Housing: For 8 hours following test substance application, the animals were kept singly in restrainers which allowed free movement of the head but prevented a complete body turn, wiping of the eyes with the paws and excluded irritation of the eye by excrements and urine.
During the acclimatisation period and after the 8-hour period in restrainers, the animals were kept singly in cages with dimensions of 425 mm x 600 mm x 380 mm
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3°C
- Humidity (%): 55% ± 15%
- Photoperiod (hrs dark / hrs light): 12/12, 150 lux
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL per eye in 3 animals - Duration of treatment / exposure:
- 1 test day
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: no washing done
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
Any other information on results incl. tables
Under the present test conditions a single instillation of 0.1 mL Hexachloraceton per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:
Corneal opacity (grade 1) was observed in animal no. 3 at 24 hours after instillation.
The fluorescein test performed after 24 hours revealed corneal staining in animal no. 3 (1 /4 of the surface).
Conjunctival redness (grade 1) was noted in all animals from 1 hour up to 24 hours, in animal no. 3 up to 48 hours after instillation.
Conjunctival chemosis (grade 2) was observed in animal nos. one and two at 1 hour after instillation. Conjunctival chemosis (grade 1) was observed in animal no. two 24 hours after instillation, in animal no. three in 1 hour to 48 hours after instillation.
The iris was not affected by instillation of the test compound.
There were no systemic intolerance reactions.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the Jaws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditionsHexachloraceton wasnon irritating to eyes, hence, no labelling is required.
- Executive summary:
Test system: acute eye irritation study by instillation into the conjunctival sac of rabbits according to EC guideline B.5. and OECD guideline 405. Test substance: Hexachloraceton
Under the present test conditions a single instillation of 0.1 ml Hexachloraceton per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:
Corneal opacity(grade 1) was observed in animal no. 3 at 24 hours after instillation.
The fluorescein test performed after 24 hours revealed corneal staining in animal no. 3 (1/4 of the surface).
Conjunctival redness(grade 1) was noted in all animals from 1 hour up to 24 hours, in animal no. 3 up to 48 hours after instillation.
Conjunctival chemosis(grade 2) was observed in animal nos. one and two at 1 hour after instillation.Conjunctival chemosis(grade 1) was observed in animal no. two 24 hours after instillation, in animal no. three in 1 hour to 48 hours after instillation.
Theiriswas not affected by instillation of the test compound.
There were no systemic intolerance reactions.
According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the Jaws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditionsHexachloraceton wasnon irritating to eyes, hence, no labelling is required.
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