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EC number: 204-254-5 | CAS number: 118-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 was considered as >22000 mg/kg when rats and mouse were treated with of 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid orally
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from Chemidplus report
- Qualifier:
- according to guideline
- Guideline:
- other: The data is from chemid plus
- Principles of method if other than guideline:
- Acute oral toxicity of chemical Pyrazolone T was determined.
- GLP compliance:
- not specified
- Test type:
- other: not reported
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 22 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Lethality of test chemical
- Mortality:
- No data available
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
- Executive summary:
Acute oral toxicity test was conducted on rat to evaluate the lethargic concentration of chemical Pyrazolone T.
The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 22 000 mg/kg bw
- Quality of whole database:
- Data is from Chem ID Plus Database
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
Data available for target 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid (118-47-8) and its read across Tartrazine (CAs no 1934-21-0) and 2-Pyrazolin-5-one, 3-methyl-1-ptolyl (CAS no 86-92-0) for acute oral toxicity are summarized as below
In Chemidplus database (2016), acute oral toxicity was given as >22000 mg/kg when rats and mouse were treated with of 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid. Therefore, LD50 was considered as >22000 mg/kg when rats and mouse were treated with of 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid orally.
Based on prediction done by using QSAR Toolbox version 3.3 (2016), acute oral toxicity was estimated in Wistar male and female rats by using 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid in the concentration of 2000 mg/kg bw orally by gavage and observed for 14 days. 50 % mortality was estimated at 1542.279174805 mg/kg bw. Therefore, estimated LD50 was considered to be 1542.279174805 mg/kg bw when Wistar male and female rats were treated with 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid orally by gavage.
In a study conducted by Lamiaet al(2016) for read across, acute oral toxicity was evaluated in Sprague-Dawley male mice by using Tartrazine in the concentration of 0, 1250 mg/kg ,2500 mg/kg ,3750 mg/kg ,5000 mg/kg , 6250 mg/kg bw in distilled water orally by gavage and observed for 3 days. No Mortality and signs and symptoms of toxicity were observed in treated mice. Therefore, LD50 was considered to be > 6250 mg/kg bw when Sprague-Dawley male mice were treated with Tartrazine orally by gavage.
In a study conducted by Sasakiet al(2002) and study report given by Feinman et al (1981) for read across, acute oral toxicity was evaluated in ddY male mice by using Tartrazine in the concentration of 2000 mg/kg bw in physiological saline orally. No Mortality was observed in treated mice. Therefore, LD50 was considered to be > 2000 mg/kg bw when ddY male mice were treated with Tartrazine orally.
In a RTECS database (2016) for read across, acute oral toxicity given for rats by using 2-Pyrazolin-5-one, 3-methyl-1-ptolyl in the concentration of 7450 mg/kg bw. 50 % mortality and behavioural somnolence (general Depressed activity) Skin and Appendages hair was observed in treated rats. Therefore, LD50 was considered to be 7450 mg/kg when rats were treated with 2-Pyrazolin-5-one, 3-methyl-1-ptolyl.
Thus, based on weight of evidence approach from above data for target 5-oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid (118-47-8) and its read across Tartrazine (CAs no 1934-21-0) and 2-Pyrazolin-5-one, 3-methyl-1-ptolyl (CAS no 86-92-0) is likely to classified as non hazardous as per the criteria of CLP regulation.
Justification for selection of acute toxicity – oral endpoint
Acute oral toxicity test was conducted on mouse to evaluate the lethargic concentration of chemical Pyrazolone T.
The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to mouse by oral route.
Justification for classification or non-classification
On the basis of available information, the substance Pyrazolone T is not expected to be acutely toxic by oral route.
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